2012 Fiscal Year Final Research Report
Evaluation of the Stress Responses Evoked by Surgical Stimuli or Pain and the Roles of Opioids in Their Control
| Project/Area Number |
21249081
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIKAWA Hiroshi 京都大学, 大学院・医学研究科, 助教 (20362501)
SEGAWA Hajime 京都大学, 大学院・医学研究科, 講師 (60263076)
SHODA Takehiro 京都大学, 大学院・医学研究科, 助教 (60335263)
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| Project Period (FY) |
2009 – 2012
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| Keywords | ストレス / 麻酔薬 / オピオイド / 亜酸化窒素 / 低酸素 / DNA損傷 |
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| Research Abstract |
This study aimed to investigate the mechanism and control of the stress responses induced by various stimuli, which is an important theme of anesthesiology and critical care medicine. The results demonstrate that the κ-opioid receptor plays an important role in the action of nitrous oxide, that the DNA damage and the mechanism other than the opioid receptor are involved in the opioid-induced immunosuppression, and that hypoxia-inducible factor-mediated gene expression is affected by various drugs and hypothermia.
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