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2011 Fiscal Year Final Research Report

Speciation of Taeniid cestodes (Echinococcus spp. and Taenia spp.) in the world and co-evolution of the host-parasite relationship

Research Project

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Project/Area Number 21256003
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionAsahikawa Medical College

Principal Investigator

ITO Akira  旭川医科大学, 医学部, 教授 (70054020)

Co-Investigator(Kenkyū-buntansha) NAKAO Minoru  旭川医科大学, 医学部, 准教授 (70155670)
NAKAYA Kazuhiro  旭川医科大学, 医学部, 准教授 (70109388)
SAKO Yasuhito  旭川医科大学, 医学部, 講師 (40312459)
YANAGIDA Tetsuya  旭川医科大学, 医学部, 助教 (40431837)
OKAMOTO Munehiro  京都大学, 霊長類研究所, 教授 (70177096)
Project Period (FY) 2009 – 2011
Keywords感染症 / 遺伝子
Research Abstract

Parasitic cestodes, Cestoda, Plathelminthes, have well been known to be hermatophroditic. Self-fertilization is the basic strategy for reproduction biology in cestodes. However, through our most recent studies on mitochondrial (haploid) and nuclear (diploid) DNA of two independent species infecting humans, Taenia saginata and Taenia asiatica have revealed that there are hybrids or hybrid derived adult tapeworms in Thailand and China where these species are sympatrically distributed. These data strongly reveal cross fertilization in the definitive host, humans, and launch “What is T. asiatica? Is it really independent species?" It is still under debates. Similar evidence showing cross fertilization between the intraspecies two, Asian and Afro/American genotypes of Taenia solium has been confirmed from larval stage of this parasite sampled in Madagascar. In Madagascar, we could have confirmed that the two genotypes are sympatrically distributed and also some hybrid individuals have been confirmed. Our work is the first one comparing both mitochondrial and nuclear genes in cestodes or platyhelminthes. These all data strongly suggest the cross fertilization in cestode reproduction biology. Molecular studies on Echinococcus spp. have also revealed that E. granulosus sensu lato is not a single species but 5 species, and a total of 9 independent species are included in the genus Echinococcus. Among these species, E. multilocularis is highly pathogenic and 3 (North American, Asian and European) genotypes have been known, but we have confirmed additional one, Mongolian genotype. The new information on the cestode speciation and identification has successfully been confirmed by the establishment of immuno- and molecular-diagnostic tools developed by our research team.

  • Research Products

    (21 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (7 results) Book (5 results)

  • [Journal Article] Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan province2012

    • Author(s)
      Li T, Ito A, Chen X, Long C, Okamoto M, Raoul F, Giraudoux P, Yanagida T, Nakao M, Xiao N,Craig PS
    • Journal Title

      Acta Trop

      Volume: 124 Pages: 152-157

    • DOI

      doi:10.1016/j.actatropica.2012.08.002.

    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms of Echinococcus granulosus in the Middle East2012

    • Author(s)
      Yanagida T, Mohammadzadeh T, Kamhawi S, Nakao M, Sadjjadi SM, Hijjawi N, Abdel-Hafez SK, Sako Y, Okamoto M, Ito A
    • Journal Title

      Parasitol Int

      Volume: 61 Pages: 599-603

    • DOI

      doi:10.1016/j.parint.2012.05.014

    • Peer Reviewed
  • [Journal Article] A Loop-mediated isothermal amplification method for a differential identification of Taenia tapeworms from human: application to a field survey2012

    • Author(s)
      Nkouawa A, Sako Y, Li T, Chen X, Nakao M, Yanagida T, Okamoto M, Giraudoux P, Raoul F, Nakaya K, Xiao N, Qiu J, Qiu D, Craig PS, Ito A.
    • Journal Title

      Parasitol Int

      Volume: 61 Pages: 723-725

    • DOI

      doi:10.1016/j.parint.2012.06.001

    • Peer Reviewed
  • [Journal Article] Molecular identification of human echinococcosis in the Altai region of Russia2012

    • Author(s)
      Konyaev SV, Yanagida T, Ingovatova GM, Shoikhet YN, Nakao M, Sako Y, Bondarev AY, Ito A.
    • Journal Title

      Parasitol Int

      Volume: 61 Pages: 711-714

    • DOI

      doi:10.1016/j.parint.2012.05.009

    • Peer Reviewed
  • [Journal Article] Molecular identification of unilocular hydatid cysts from domestic ungulates in Ethiopia: implications for human infections2012

    • Author(s)
      Hailemarian Z, Nakao M, Menkir S, Lavikainen A, Yanagida T, Okamoto M, Ito A.
    • Journal Title

      Parasitol Int

      Volume: 61 Pages: 375-377

    • DOI

      doi:10.1016/j.parint.2012.01.007

    • Peer Reviewed
  • [Journal Article] Recent hybridization between Taenia asiatica and Taenia saginata2012

    • Author(s)
      Yamane K, Suzuki Y, Tachi E, Li TY, Chen XW, Nakao M, Nkouawa A, Yanagida T, Sako Y, Ito A, Sato H, Okamoto M.
    • Journal Title

      Parasitol Int

      Volume: 61 Pages: 351-355

    • DOI

      doi:10.1016/j.parint.2012.01.005.

    • Peer Reviewed
  • [Journal Article] Phylogenetic relationships within Echinococcus and Taenia tapeworms (Cestoda: Taeniidae): an inference from nuclear protein-coding genes2011

    • Author(s)
      Knapp J, Nakao M, Yanagida T, Okamoto M, Saarma U, Lavikainen A, Ito A.
    • Journal Title

      Molecular Phylogenetics and Evolution

      Volume: 61 Pages: 628-638

    • DOI

      doi:10.1016/j.ympev.2011.07.022.

    • Peer Reviewed
  • [Journal Article] Isolated intradural-extramedullary spinal cysticercosis: a case report.2011

    • Author(s)
      Jongwietiwes U, Yanagida T, Ito A, Kline S.
    • Journal Title

      J Travel Med

      Volume: 18 Pages: 284-287

    • DOI

      doi:10.1111/j.1708-8305.2011.00535.x.

    • Peer Reviewed
  • [Journal Article] Echinococcus multilocularis: Identification and functional characterization of cathepsin B-like peptidases from metacestode.2011

    • Author(s)
      Sako Y, Nakaya K, Ito A.
    • Journal Title

      Exp Parasitol

      Volume: 27 Pages: 693-701

    • DOI

      doi:10.1016/j.exppara.2010.11.005.

    • Peer Reviewed
  • [Presentation] Invited speaker on "The present situation of alveolar Echinococcosis and cystic Echinococcosis in Mongolia" at "Molecular Epidemiology"2011

    • Organizer
      session at 24^<th> International Congress of Hydatidology
    • Place of Presentation
      Urumqi, China
    • Year and Date
      20110914-18
  • [Presentation] Invited speaker on "Histopathological, serological, and molecular confirmation of alveolar echinococcosis cases in Mongolia".2010

    • Organizer
      At 3^<rd> International Symposium on "Emerging Infectious Diseases"
    • Place of Presentation
      Ulaanbaatar, Mongolia
    • Year and Date
      20100729-30
  • [Presentation] Key note speaker on "The Recent advances in serodiagnosis of echinococcosis" at "Alveolar echinococcosis"2009

    • Organizer
      session at 23^<rd> International Congress of Hydatidology
    • Place of Presentation
      Colonia, Uruguay
    • Year and Date
      20091210-12
  • [Presentation] Invited speaker on "Phylogeny and phylogeography of Echinococcus" at the workshop on "Biology and Biochemistry of Echinococcus"2009

    • Organizer
      at 23^<rd> International Congress of Hydatidology
    • Place of Presentation
      Colonia, Uruguay
    • Year and Date
      20091210-12
  • [Presentation] Key note speaker on "Advances in Diagnosis of Neurocysticercosis" at the First Indonesian Congress of Neurological DiseasesKey note speaker on "Advances in Diagnosis of Neurocysticercosis"2009

    • Organizer
      at the First Indonesian Congress of Neurological Diseases
    • Place of Presentation
      Denpasar, Indonesia
    • Year and Date
      20091113-15
  • [Presentation] Invited speaker on "Echinococcosis: detection of patients and identification of parasites"2009

    • Organizer
      at the 2^<nd> Baltic Forum on Zoonoses, St Peterburg
    • Place of Presentation
      Russia
    • Year and Date
      20091002-03
  • [Presentation] Special lecture on "Immuno- and Molecular-diagnosis of Echinococcosis"2009

    • Organizer
      at 10th International Congress of the Asian Society of Clinical Pathology and Laboratory Medicine, Ulaanbaatar
    • Place of Presentation
      Mongolia
    • Year and Date
      20090910-11
  • [Book] In: Molecular Detection of Human Parasitic Pathogens (ed. by Liu D)2012

    • Author(s)
      Ito A, Nakao M, Sako Y, Yanagida T, Nakaya K, Knapp J, Ishikawa Y
    • Total Pages
      249-263
    • Publisher
      Chapter Echinococcus and Echinococcosis
  • [Book] In: Molecular Detection of Human Parasitic Pathogens (ed. by Liu D)2012

    • Author(s)
      Okamoto M, Ito A
    • Total Pages
      295-305
    • Publisher
      Chapter Taenia
  • [Book] In: Zoonoses. Palmer SR, Lord Soulsby, Torgerson PR, Brown DWG (eds)2011

    • Author(s)
      Flisser A, Craig PS, Ito A.
    • Total Pages
      627-644
    • Publisher
      Taenia solium, Taenia saginata and Taenia asiatica
  • [Book] In: Handbook of Nucleic Acid Purification (ed. by Liu D), CRC Press, Taylor & Francis Group, Boca Raton2009

    • Author(s)
      Okamoto M, Ito A.
    • Total Pages
      271-291
    • Publisher
      Chapter 13. Purification of nucleic acids from helminthes
  • [Book] In: Foodborn Pathogens (ed. by Liu D), CRC Press, Taylor & Francis Group, Boca Raton2009

    • Author(s)
      Ito A, Nakao M, Sako Y, Nakaya K, Okamoto M, Yanagida T.
    • Total Pages
      827-838
    • Publisher
      Chapter 62. Taeniasis

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Published: 2014-08-29   Modified: 2017-10-13  

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