Roles of fatty acids and fatty acid binding proteins for regulating proliferation and differentiation of neural stem cells

2011 Fiscal Year Final Research Report

• Project/Area Number: 21300115
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Tohoku University
• Principal Investigator: OSUMI Noriko 東北大学, 大学院・医学系研究科, 教授 (00220343)
• Project Period (FY): 2009 – 2011
• Keywords: 神経幹細胞 / 高度不飽和脂肪酸 / アラキドン酸 / ドコサヘキサエン酸 / 脂肪酸結合タンパク質 / 細胞増殖 / 細胞分化

Research Abstract

Neurosphere assays using neural stem cells (NSCs)derived from the wild type rat embryo revealed that arachidonic acid (ARA)and docosahexanoic acid (DHA)regulate proliferation and differentiation of NSCs in a stage-dependent manner (Sakayori et al., 2011). From neurosphere assays using NSCs derived from mice deficient for fatty acid binding protein 7 (Fabp7), it is shown that Fabp7 is required for proliferation and differentiation of NSCs (in prep).

Research Products

• [Journal Article] Differential Proliferation Rhythm of Neural Progenitor and Oligodendrocyte Precursor Cells in the Young Adult Hippocampus (2011)
  • Author(s): Matsumoto, Y., Tsunekawa, Y., Nomura, T., Suto, F., Matsumata, M., Tsuchiya, S., and Osumi, N.
  • Journal Title: PLoS ONE Volume: 6(11) Pages: e27628
  • Peer Reviewed
• [Journal Article] Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells (2011)
  • Author(s): Sakayori, N., Maekawa, M., Numayama-Tsuruta, K., Katura, T., Moriya, T. and Osumi, N.
  • Journal Title: Genes Cells Volume: 16(7) Pages: 778-790
  • Peer Reviewed
• [Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain-and sex-dependent eye abnormalities in mice (2010)
  • Author(s): Maekawa, M., Iwayama, Y., Watanabe, A., Nozaki, Y., Ohnishi, T., Ohba, H., Toyoshima, M., Hamazaki, K., Osumi, N., Aruga, J. and Yoshikawa, T.
  • Journal Title: Biochem Biophys Res Commun Volume: 402(2) Pages: 431-437
  • Peer Reviewed
• [Journal Article] Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice (2010)
  • Author(s): Hara, Y., Nomura, T., Yoshizaki, K., Jonas Frisen, J., and Osumi, N.
  • Journal Title: Stem Cells Volume: 28(5) Pages: 974-983
  • Peer Reviewed
• [Journal Article] Polymorphism screening of brain-expressed FABPs7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects (2010)
  • Author(s): Maekawa, M., Iwayama, Y., Arai, R., Nakamura, K., Ohnishi, T., Toyota, T., Tsujii, M., Okazaki, Y., Osumi, N., Owada, Y., Mori, N. and Yoshikawa, T.
  • Journal Title: J Hum Genet Volume: 55(2) Pages: 127-130
  • Peer Reviewed
• [Journal Article] A novel missense mutation (Leu46Val)of PAX6 found in an autistic patient (2009)
  • Author(s): Maekawa, M., Iwayama, Y., Nakamura, K., Sato, M., Toyota, T., Ohnishi, T., Yamada, K., Miyachi, T., Tsujii, M., Hattori, E., M aekawa, N., Osumi, N., Mori, N. and Yoshikawa, T.
  • Journal Title: Neurosci Lett Volume: 462(3) Pages: 267-271
  • Peer Reviewed
• [Journal Article] Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses (2009)
  • Author(s): Maekawa, M., Takashima, N., Matsumata, M., Ikegami, S., Kontani, M., Hara, Y., Kawashima, H., Owada, Y., Kiso, Y., Yoshikawa, T., Inokuchi, K. and Osumi, N.
  • Journal Title: PloS One Volume: 4(4) Pages: e5085
  • Peer Reviewed
• [Presentation] Impact of postnatal and adult neurogenesis on animal behavior (2011)
  • Author(s): Osumi, N.
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics
  • Place of Presentation: 北海道・ニセコ
  • Year and Date: 2011-06-12
• [Presentation] Neurogenesis-Its implication in and application for mental diseases (2011)
  • Author(s): Osumi, N.
  • Organizer: Cold Spring Harbor Asia Francis Crick Neurobiology Symposium
  • Place of Presentation: 中国・蘇州
  • Year and Date: 2011-04-17
• [Presentation] 神経系前駆細胞の増殖と分化に対するアラキドン酸とドコサヘキサエン酸の効果の解析 (2010)
  • Author(s): 酒寄信幸、前川素子、松股美穂、沼山恵子、若松義雄、大隅典子
  • Organizer: 第33回日本分子生物学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] The effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells (2010)
  • Author(s): Sakayori, N., Maekawa, M., Numayama-Tsuruta, K. and Osumi, N.
  • Organizer: Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-14
• [Presentation] 脂肪酸シグナルと神経新生～精神疾患病態への関与 (2010)
  • Author(s): 大隅典子
  • Organizer: 第18回日本精神行動遺伝医学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-18
• [Presentation] The role of FABPs in postnatal hippocampal neurogenesis and function (2010)
  • Author(s): Matsumata, M., Maekawa, M., Arime, Y., Owada, Y., Sora, I., Yoshikawa, T. and Osumi, N.
  • Organizer: 第33回日本神経科学大会 Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] 成体マウス海馬の神経新生及び機能における脂肪酸結合タンパク質FABPの役割 (2010)
  • Author(s): 松股美穂、前川素子、有銘預世布、大和田祐二、曽良一郎、吉川武男、大隅典子
  • Organizer: 日本分子生物学会第10回春期シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07
• [Presentation] The effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells (2010)
  • Author(s): Osumi, N.
  • Organizer: 9th Conference of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)
  • Place of Presentation: Maastricht, Netherlands
  • Year and Date: 2010-05-31
• [Presentation] Fatty acid signals in neurogenesis : for potential prevention and treatment of psyichiatric diseases (2010)
  • Author(s): Osumi, N.
  • Organizer: Adult Neurogenesis : Structure and Function
  • Place of Presentation: Frauenchiemsee, Germany
  • Year and Date: 2010-05-28
• [Presentation] 神経系前駆細胞におけるアラキドン酸とドコサヘキサエン酸の効果の解析 (2010)
  • Author(s): 酒寄信幸、大隅典子
  • Organizer: 第8回幹細胞シンポジウム
  • Place of Presentation: 淡路島
  • Year and Date: 2010-05-13
• [Presentation] 神経系前駆細胞の増殖と分化におけるアラキドン酸とドコサヘキサエン酸の効果の解析 (2009)
  • Author(s): 酒寄信幸, 沼山恵子, 大隅典子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Roles of fatty acid binding proteins and polyunsaturated fatty acids in hippocampal neurogenesis (2009)
  • Author(s): Osumi, N.
  • Organizer: 6th International Society of Developmental Biologists Congress 2009
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2009-09-08
• [Presentation] Fatty acid signals in neurogenesis : for potential prevention and treatment of psychiatric diseases (2009)
  • Author(s): Osumi, N.
  • Organizer: Neurogenesis 2009 Hippocampal neurogenesis : Its implication in neural functions and mental diseases
  • Place of Presentation: 淡路
  • Year and Date: 2009-06-02
• [Book] Eds. Tatsunori, S., Kazunobu, S., Jack M. Parent and Arturo Alvarez-Buylla (2011)
  • Author(s): Osumi, N. and Nannan, G.
  • Total Pages: 109-131
  • Publisher: springer
• [Remarks]
  • URL: http://www.dev-neurobio.med.tohoku.ac.jp/en/