2012 Fiscal Year Final Research Report
Analysis of molecular mechanisms underlying neuronal development and neuronal maintenance
| Project/Area Number |
21300122
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SANADA Yoshikado 東京大学, 大学院・理学系研究科, 准教授 (50431896)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 神経前駆細胞 / 神経細胞移動 / 神経保護 |
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| Research Abstract |
In the developing neocortex in mice, neural progenitor cells give rise to neurons. In the present study, I identified a novel regulatory mechanism contributing to neuronal differentiation of neural progenitor cells. Also, I identified a molecule with neuroprotective role and neuronal overexpression of the molecule in ALS mice alleviated motor neuron degeneration and delayed onset of the disease.
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