2011 Fiscal Year Final Research Report
Chromatin dynamics in regulation of activity-dependent transcription in neurons.
| Project/Area Number |
21300123
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
NAKASHIMA Kinichi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (80302892)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIZAWA Takumi 群馬大学, 大学院・医学系研究科, 准教授 (30531115)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ニューロン / クロマチン / 転写 |
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| Research Abstract |
We have identified two different types of genes induced in a neuronal activity-dependent manner ; one is immediately expressed while the other expressed lately. We examined differences in chromatin modifications in two groups of genes and analyzed dynamic behavior of chromatin related proteins which are assumedly involved in activity-dependent transcription. We found that chromatin modifications, recruitment of RNA polymerase II and the negative elongation factor are different between the two groups. These results demonstrate molecular basis for temporal regulation of activity-dependent genes.
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[Journal Article] Role of GLI2 in the growth of human osteosarcoma2011
Author(s)
Nagao, H., Ijiri, K., Hirotsu, M., Ishidou, Y., Yamamoto, T., Nagano, S., Takizawa, T., Nakashima, K., Komiya, S. & Setoguchi, T.
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Journal Title
J Pathol
Volume: 224
Pages: 169-179
Peer Reviewed
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