2012 Fiscal Year Final Research Report
A study for the generation mechanism and physiological relevance of left-right asymmetry of the brain
| Project/Area Number |
21300125
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyushu University |
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Principal Investigator |
ITO Isao 九州大学, 大学院・理学研究院, 准教授 (20183741)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Shigeru 慶応義塾大学, 文学部, 教授 (30051907)
SAKATA Shougo 広島大学, 総合科学研究科, 教授 (50153888)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 分子・細胞神経科学 / 脳の左右差 / 海馬 |
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| Research Abstract |
How is brain asymmetry generated? What is the meaning of brain asymmetry in higher-order brain functions? To address these fundamental questions, we conducted electrophysiological and behavioral studies using several strains of mutant mice. We found that a protein, known to be important in cellular immunity, was critical for the generation of asymmetrical neuronal circuitry in the brain. The transgenic mice lacking this protein showed deficits in the retention of spatial memory.
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