2011 Fiscal Year Final Research Report
Input responsiveness of neuronal circuits and its modulation by neurotransmitters.
| Project/Area Number |
21300127
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
IMOTO Keiji 生理学研究所, 生体情報研究系, 教授 (00176512)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経回路 / シナプス伝達 / フィードフォワード抑制 / ダイナミッククランプ / てんかん |
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| Research Abstract |
We investigated timing dependency of two synaptic inputs to layer 4 neurons projecting from thalamus using patch clamp recording from brain slice preparations. The optimal timing of quasi-simultaneous inputs is modulated by neuromodulators. This switching-like behavior of the circuit may be a neuronal correlate of switching of attention and wakefulness. We also investigated the role of the basal ganglia in absence epilepsy using calcium channel-mutant mice, which are used as a model animal for epilepsy. We found functional activity of hyperpolarization-activated cation channel is reduced in the subthalamic nucleus. The reduction enhanced excitability of subthalamic neurons, which resulted in prolongation of abnormal rhythmic activity of absence epilepsy.
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Research Products
(53 results)
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[Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system2009
Author(s)
Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y
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Journal Title
Cell Metab
Volume: 10
Pages: 466-480
Peer Reviewed
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[Journal Article] Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome2009
Author(s)
Itoh H, Sakaguchi T, Ding WG, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M.
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Journal Title
Circ Arrhythm Electrophysiol
Volume: 2
Pages: 511-23
Peer Reviewed
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[Journal Article] Kinase-dead knock-in mouse reveals an essential role of CaMKII-alpha kinase activity in dendritic spine enlargement, LTP and learning2009
Author(s)
Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S
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Journal Title
J Neurosci
Volume: 29
Pages: 7607-7618
Peer Reviewed
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[Presentation] Kinase activity of CaMKIIa is essential for structural, functional and behavioral expression of synaptic memory2009
Author(s)
Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S
Organizer
第32回日本神経科学大会
Place of Presentation
(愛知県)名古屋国際会議場
Year and Date
2009-09-17
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[Presentation] The role of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase II in hippocampal synaptic plasticity and learning2009
Author(s)
Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, Watanabe M, Hatanaka N, Totsuka M, Yagi T, Obata K, Imoto K, Yanagawa Y, Manabe T, Okabe S
Organizer
第36回国際生理学会大会・第86回日本生理学会大会
Place of Presentation
(京都府)国立京都国際会館
Year and Date
2009-07-28
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