2011 Fiscal Year Final Research Report
Functional analysis of the roles of Runx family transcription factors in the neural development
| Project/Area Number |
21300130
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
SHIGA Takashi 筑波大学, 医学医療系, 教授 (50178860)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SENZAKI Kouji 筑波大学, 医学医療系, 講師 (30333280)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 転写因子 / 細胞分化 / 細胞増殖 / 軸索投射 / 神経発生 / 遺伝子改変マウス |
|---|
| Research Abstract |
We examined the roles of Runx1 and Runx3 transcription factors in the neural development. We showed (1) Runx1 promotes the neuronal differentiation of dorsal root ganglion cells, (2) Runx3 regulates the subtype specification and axonal projection of mechanoreceptive sensory neurons in the trigeminal ganglion, and (3) Runx1 is involved in the axonal projection and synapse formation of the hypoglossal motoneurons.
|
