2011 Fiscal Year Final Research Report
Analyses of neuropathogenic effects ofβsynuclein using a novel mouse model of synucleinopathies and post mortem brains
| Project/Area Number |
21300135
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | 財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2009-2010) |
|---|
Principal Investigator |
HASHIMOTO Makoto 財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (50189502)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WAKABAYASHI Koichi 弘前大学, 医学部, 教授 (50240768)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | アミロイド / シヌクレイン / パーキンソン病 / レビー小体 / 神経変性疾患 / 蛋白凝集 / 遺伝子変異 |
|---|
| Research Abstract |
We show that transgenic(tg) mice expressing DLB-linked P123Hβs develop progressive neurodegeneration, as characterized by axonal swelling, astrogliosis and behavioural abnormalities, such as memory disorder. Furthermore, cross-breeding of P123Hβs tg mice withαs tg mice, greatly enhanced neurodegeneration phenotypes, suggesting that P123Hβs is pathogenic and cooperates with s to stimulate neurodegeneration in mouse brain. Thus, it is expected that P123Hβs tg mice will be a invaluable tool for the elucidation of the mechanism and development of novel treatment forα-synucleinopathies.
|
-
-
-
-
-
[Journal Article] The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1βunder acidic extracellular pH in LPS-primed microglial cells2011
Author(s)
Takenouchi T, Iwamaru Y, Sugama S, Tsukimoto M, Fujita M, Sekigawa A, Sekiyama K, Sato M, Kojima S, Conti B, Hashimoto M, Kitani H
-
Journal Title
J Neurochem
Volume: 117(4)
Pages: 712-23
Peer Reviewed
-
-
[Journal Article] Aβ-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain2010
Author(s)
Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, LaSpada AR, Masliah E, Inoue S, Hashimoto M
-
Journal Title
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells2009
Author(s)
Takenouchi T, Nakai M, Iwamaru Y, Sugama S, Tsukimoto, M, Fujita M, Wei J, Sekigawa A, Sato M, Kojima, S, Kitani H, Hashimoto M
-
Journal Title
J Immunol
Volume: 182(4)
Pages: 2051-62
Peer Reviewed
-
-
-
-
-
-
-
[Presentation] A b-synuclein mutation linked to familial dementia with Lewy bodies produces neurodegeneration when expressed in mouse brain2011
Author(s)
Fujita, M. Sekiyaam, K, Sekigawa, A Yoshiki Takamatsu, Rockenstein, E, Masliah, M, Hashimoto, M
Organizer
AD/PD 2011
Place of Presentation
バルセロナ
Year and Date
2011-03-14
-
-
[Presentation] Non-apoptotic cell death in hippocampus and cerebral cortex of bigenic mice overexpressing both beta-synuclein(P123H) and alpha-synuclein2010
Author(s)
Fujita, M., Sugama, S., Sekiyama, K., Sekigawa, A., Tsukui, T., Inoue, S., Hashimoto, M
Organizer
BMB2010(第33回日本分子生物学会第83回日本生化学会合同大会)
Place of Presentation
神戸ポートピアアイランド
Year and Date
2010-12-07
-
-
-
-
-
-
