2011 Fiscal Year Final Research Report
Molecular mechanisms of subcellular synapse organization in cerebellar Purkinje neurons
| Project/Area Number |
21300137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANAKA Kohichi 東京医科歯科大学, 大学院・疾患生命科学研究部, 教授 (80171750)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小脳 / 抑制性ニューロン / プルキンエ細胞 / 星状細胞 / 籠細胞 / 登状線維 |
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| Research Abstract |
A remarkable feature of neuronal wiring is its specificity. The subcellular organization of glutamatergic and GABAergic inputs along Purkinje neurons is essential for information processing in cerebellum. In this study, we demonstrated that RBP-J promotes the neurogenesis of stellate and basket cells : two sets of inhibitory neurons that innervate selectively dendrites and axonal initial segments of Purkinje neurons, respectively. In addition. I found that climbing fibers(CF_s) that innervate proximal dendrites of Purkinje neurons in zebrin II immunoreactive(Z+) zones have a higher release probability than CFs in Z-zones.
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[Journal Article] RBP-J promotes the maturation of neuronal progenitors2011
Author(s)
Komine, O., Nagaoka, M., Hiraoka, Y., Hoshino, M., Kawaguchi, Y., Pear, E. S., Tanaka, K.
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Journal Title
Dev Bio
Volume: 354
Pages: 44-54
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