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2011 Fiscal Year Final Research Report

Identification of genetic components in a rat model of essential tremor

Research Project

  • PDF
Project/Area Number 21300153
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKyoto University

Principal Investigator

KURAMOTO Takashi  京都大学, 医学研究科, 准教授 (20311409)

Co-Investigator(Kenkyū-buntansha) OHNO Yukihiro  大阪薬科大学, 薬学部, 教授 (00432534)
Co-Investigator(Renkei-kenkyūsha) KUWAMURA Mitsuru  大阪府立大学, 大学院・情報学研究科, 准教授 (20244668)
Project Period (FY) 2009 – 2011
Keywords疾患モデル / 亜系統 / 本態性振戦 / 順遺伝学 / ラット / アスパルトアシラーゼ / HCN1チャネル / 下オリーブ核
Research Abstract

We established TRM rat as a good model of essential tremor(ET). Using the rat and mouse model systems, we identified Hcn1 and Aspa as genetic components essential to express ET. Interestingly, either Hcn1 or Aspa alone could not induce any ET in rat or mouse model system. Simultaneous inactivation of both Hcn1 and Aspa gene functions could induce ET. These findings suggest that HCN1 and ASPA are also essential to express the human ET.

  • Research Products

    (18 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] A rat model ofhypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene2011

    • Author(s)
      Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T
    • Journal Title

      BMC Genet

      Volume: 12巻 Pages: 91

    • Peer Reviewed
  • [Journal Article] Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat2011

    • Author(s)
      Kuwamura M, Inumaki K, Tanaka M, Shirai M, Izawa T, Yamate J, FranklinRJ, Kuramoto T, Serikawa T
    • Journal Title

      Brain Res

      Volume: 1389巻 Pages: 161-168

    • Peer Reviewed
  • [Journal Article] A mutation in the gene encoding mitochondrial Mg2+ channel MRS2 results indemyelination in the rat2011

    • Author(s)
      Kuramoto T, Kuwamura M, Tokuda S, Izawa T, Nakane Y, Kitada K, Akao M, Guenet JL, Serikawa T
    • Journal Title

      Plops Genet

      Volume: 7巻

    • Peer Reviewed
  • [Journal Article] Kyoto rhino rats derived by ENUmutagenesis undergo congenital hairloss and exhibit focalglomerulosclerosis2011

    • Author(s)
      Kuramoto T, Kuwamura M, Tagami F, Mashimo T, Nose M, Serikawa T
    • Journal Title

      Exp Anim

      Volume: 60巻 Pages: 57-63

    • Peer Reviewed
  • [Journal Article] A novel middle-wavelengthopsin(M-opsin) null-mutation in the retinal cone dysfunction rat2010

    • Author(s)
      Xie B, Nakanishi S, Guo Q, Xia F, YanG, An J, Li L, Serikawa T, Kuramoto T, Zhang Z
    • Journal Title

      Exp Eye Res

      Volume: 91巻 Pages: 26-33

    • Peer Reviewed
  • [Presentation] 本態性振戦モデルTremorラットにおける中枢神経系薬物の作用評価2011

    • Author(s)
      今奥
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      20110915-17
  • [Presentation] A rat model of hypohidroticectodermal dysplasia carries amissense mutation in Edradd gene2011

    • Author(s)
      庫本
    • Organizer
      Rat Genomics & Models
    • Place of Presentation
      Cold Spring Horbor Laboratory(米国)
    • Year and Date
      2011-12-08
  • [Presentation] Genetic components in a rat model of essential tremor2011

    • Author(s)
      庫本
    • Organizer
      第18回国際ラット遺伝システムワークショップ
    • Place of Presentation
      京都大学(京都市)
    • Year and Date
      2011-12-02
  • [Presentation] Behavioral and pharmacological studies in Tremor rats, a novel rat model of human essential tremor2011

    • Author(s)
      今奥
    • Organizer
      第18回国際ラット遺伝システムワークショップ
    • Place of Presentation
      京都大学(京都市)
    • Year and Date
      2011-12-02
  • [Presentation] Tremorラットにおけるβ受容体遮断薬の振戦抑制メカニズムの解析2011

    • Author(s)
      多田羅
    • Organizer
      第21回臨床精神薬理学会・第41回日本神経精神薬理学会合同年回
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-10-28
  • [Presentation] ラットモデルを用いた本態性振戦の遺伝要因の解明2011

    • Author(s)
      庫本
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-09-17
  • [Presentation] ラットモデルを用いた本態性振戦の遺伝要因の解明2011

    • Author(s)
      庫本
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-26
  • [Presentation] Tremorラットにおける振戦行動の薬理学的解析2011

    • Author(s)
      大野
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2011-05-12
  • [Presentation] Tremorラットにおける脳内Fos発現解析2011

    • Author(s)
      今奥
    • Organizer
      第57回日本実験動物学会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2011-05-12
  • [Presentation] Neural mechanisms underlying tremor induction in Tremor rats, a novel model of human essential tremor2011

    • Author(s)
      多田羅
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-03-23
  • [Presentation] 新たなヒト本態性振戦モデルTremorラットの行動薬理学的解析2009

    • Author(s)
      清水
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-11-14
  • [Presentation] 新たなヒト本態性振戦モデルTremorラットにおける前脳Fos発現分布の解析2009

    • Author(s)
      今奥
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-11-14
  • [Remarks]

    • URL

      http://www.anim.med.kyoto-u.ac.jp/Kuramoto/home.htm

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Published: 2013-07-31  

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