2011 Fiscal Year Final Research Report
Research and development of hypoxia-detecting luminescent probe iridium complex and its application to endoscopic imaging probes
| Project/Area Number |
21300159
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TOBITA Seiji 群馬大学, 大学院・工学研究科, 教授 (30164007)
HOSAKA Masahiro 秋田県立大学, 生物資源科学部, 教授 (80311603)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 分子イメージング / 有機EL / イリジウム錯体 / 低酸素病態 / 発光プローブ / リン光 / 酸素消光 |
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| Research Abstract |
The drawback of luminescent probes is low tissue penetration of its excitation/emission light. To overcome this limitation, we created a new BTO derivative BTPHSA, which gives 710 nm emission light in the near infrared region. This probe enables tumors visible, which are transplanted 1.5 cm deep intraperitoneally from the skin surface in mice. To further increase tissue-accumulating capability of BTP analogues, we created dimethyl moiety-added BTP, BTO-DM, which enables tumors visible by a tenth of regular dosage of BTP in mice. We believe these innovative BTP derivatives will open up their new application to endoscopic imaging.
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