2011 Fiscal Year Final Research Report
Development of X-ray sensitizing therapy by precisely designed polymers bearing heavy metals
| Project/Area Number |
21300164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
ANDO Tsuyoshi 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (60324654)
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| Co-Investigator(Kenkyū-buntansha) |
TANIHARA Masao 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (50294286)
HIROHARA Shiho 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (70413804)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナノバイオロジー / ナノメディスン / X線増感 / スターポリマー |
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| Research Abstract |
In this project, X-ray sensitizing material was developed for radiation therapy of cancer to reduce irradiation dose. Metal-bearing star polymer, which has many metals in its core, was prepared by living radical polymerization and was employed as an X-ray sensitizer. The obtained metal-bearing star polymer was added to HeLa cells and incubated. X-ray was then irradiated to the cells. More cells containing the star polymer were killed than that without the star polymer, which indicates that the metal-containing star polymer actually worked as an X-ray sensitizer.
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