2011 Fiscal Year Final Research Report
Development of instrumental methods and systems for fluorescence lifetime measurements for a screening purpose of tumor diagnosis
| Project/Area Number |
21300167
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IWATA Tetsuo 徳島大学, 大学院・ソシオテクノサイエンス研究部, 教授 (50304548)
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| Co-Investigator(Kenkyū-buntansha) |
ARAKI Tsutomu 大阪大学, 大学院・基礎工学研究科, 教授 (50136214)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 医用光学 / 生体計測 / 腫瘍診断蛍光寿命 / 分光計測 / 赤外蛍光 / 位相変調法 |
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| Research Abstract |
Comprehensive studies have been carried out concerning on instrumental and data-processing methods for fluorescence lifetime measurements with a purpose of enhancing capabilities of discriminating tumor cells from normal cells. Our final goal is developing diagnostic metrology. In a series of studies, we have developed a phase-modulation fluorometer using a phase-modulated light source, a photon-counting-type phase-modulation fluorometer, and a near-infrared fluorometer using a radio-frequency lock-in amplifier. By using these systems, we have measured a fluorescence lifetime of the indocyanine green solution and that of 6 1×10^<-6> M coumarin 152 in ethanol with precision.
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