2011 Fiscal Year Final Research Report
Research on micromachine technology for transplantation surgery based on tissue engineering
| Project/Area Number |
21300173
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIMOTO Kenichi 立命館大学, 理工学部, 助教 (90435777)
KOBAYASHI Taizo 立命館大学, 立命館グローバル・イノベーション研究機構, ポストドクトラルフェロー (20557433)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMATO Masayuki 東京女子医科大学, 医学部, 教授 (40267117)
TAKAHASHI Masayo 独立行政法人理化学研究所, 発生再生科学総合研究センター, チームリーダー (80252443)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 再生医療移植技術 / マイクロマシン / 細胞シート / バルーンアクチュエータ |
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| Research Abstract |
Recently, transplantation surgery based on tissue engineering is strongly expected to cure inextirpable disease or congenital failure effectively. Transplantation surgery in an eye is one of the most challenging medical technologies because an eye has only tiny surgical field and is very fragile. Therefore, it is expected to develop the minimally inversion medical technology for transplantation surgery in an eye. We have interested in the Retinal Pigment Epithelium(RPE) sheet transplantation and developed a transplantation surgical tool using pneumatic balloon actuator(PBA).
Toward design optimization of pneumatic balloon actuators(PBAs), we have performed FEM simulation and demonstrated its applicability to compute and characterize the bending motion of PBAs fabricated from PDMS(polydimethylsiloxane)-based materials. It is shown that typical PBA motions could be successfully captured in the present simulation through the comparison of the computational results obtained in the linearly-elastic region with the actual motions of fabricated devices. Successive ex-vivo and in-vivo experiments through collaborations will verify the practical usability of the improved tool.
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Research Products
(12 results)
