2011 Fiscal Year Final Research Report
Preparation of bioresorbable bone substitutes incorporated in bone metabolism
| Project/Area Number |
21300175
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
IOKU Koji 東北大学, 大学院・環境科学研究科, 教授 (60212726)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Tohru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00211029)
KAMITAKAHARA Masanobu 東北大学, 大学院・環境科学研究科, 准教授 (80362854)
WATANABE Noriaki 東北大学, 大学院・環境科学研究科, 助教 (60466539)
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| Project Period (FY) |
2009 – 2011
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| Keywords | バイオマテリアル / 吸収性骨代替材料 |
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| Research Abstract |
A fabrication process of Ca-deficient HA with controlled composition and morphology of the particles which construct the HA ceramics was established by selecting the starting material and hydrothermal conditions. The possibility that the Ca-deficient composition and morphology of the particles affect the behavior of the HA ceramics in vivo was revealed. Moreover, it was revealed that the rod-shaped particles prevent the brittle fracture. From these results, we obtained the basic knowledge about the creation of bioresorbable bone substitute materials.
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