2011 Fiscal Year Final Research Report
Preparation of biocompatible polymer nanoparticles as cell-function analysis biodevices
| Project/Area Number |
21300176
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナノ粒子 / 細胞機能 / 生体親和性 / リン脂質ポリマー / 量子ドット / 磁性粒子 / 細胞膜透過ペプチド |
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| Research Abstract |
Polymeric nanoparticles for new cell-function analytical biodevices were prepared. The polymeric nanoparticles covered with phospholipid polymer, which functioned as artificial cell membrane, and quantum dots were embedded in the polymer nanoparticles. Moreover, special functional biomolecules, oligopeptide, were introduced on the surface to understand their functions to the cell responses. Effects of phospholipid polymer were clearly demonstrated that the nanoparticles did not internalize to the cells without biomolecules on the surface. On the other hand, when the some specific oligopeptide were immobilized on the surface, the nanoparticles turned to cell-penetrative. That is, it could be concluded that the chemical structure, sequence, and density of the oligopeptide strongly influence cell internalization of the nanoparticle.
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