2011 Fiscal Year Final Research Report
Development of liver-target therapy based on cellular modification technology
| Project/Area Number |
21300180
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
OHASHI Ohashi 東京女子医科大学, 医学部, 准教授 (40364062)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Masamichi 東京女子医科大学, 医学部, 講師 (00338980)
TATSUMI Kohei 東京女子医科大学, 医学部, 助教 (70555432)
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| Co-Investigator(Renkei-kenkyūsha) |
IWATA Hiroo 京都大学, 再生医科学研究所, 教授 (30160120)
MIZUGUCHI Hiroyuki 大阪大学, 薬学研究科, 教授 (50311387)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞・組織工学 / 再生医療 / 細胞治療 / 遺伝子治療 / 細胞表面修飾 / 免疫隔離 |
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| Research Abstract |
The present study was conducted to establish two different approaches for modifying hepatocytes. First, HGF gene transduction was conducted to isolated hepatoytes in suspension. The study showed that transplantation of HGF-transduced hepatocytes in vivo resulted in significant higher engraftment due to protection from apoptotis that occur after being transplanted in vivo. Second, hepatocyte surface modification technology was established using PEG-lipids. This modification allows hepatocytes to being coated ultra-thin polymer complexes.
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