2012 Fiscal Year Final Research Report
Understanding and control of biodegradability of bioabsorbable Mg alloys
| Project/Area Number |
21300183
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
YAMAMOTO Akiko 独立行政法人物質・材料研究機構, 生体機能材料ユニット, グループリーダー (20343882)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAI Toshiji 神戸大学, 大学院工学研究科, 教授 (40254429)
SHIMIZU Yoshinaka 東北大学, 大学院歯学研究科, 助教 (30302152)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 生体機能材料 / 生体吸収性金属材料 |
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| Research Abstract |
Degradation properties of Mg alloys depend on the kind of alloys, which relates to the amount of gas cavity formed in the soft tissue surrounding the implant site. Extraordinary inflammation was not observed even for the Mg alloy having rapid degradation rate. The local pH increase due to the OH- release accompanying the degradation may suppress cell growth when it goes over the acceptable range of cells. Coating of pure Mg with bioabsorbable medical polymers is effective to reduce initial degradation rate of pure Mg and successfully improves cytocompatibility.
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