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2011 Fiscal Year Final Research Report

Development of virus filter using electret apatite complex adsorbent

Research Project

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Project/Area Number 21300184
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo Institute of Technology

Principal Investigator

IKOMA Toshiyuki  東京工業大学, 大学院・理工学研究科, 准教授 (20370306)

Co-Investigator(Kenkyū-buntansha) TANAKA Junzo  東京工業大学, 大学院・理工学研究科, 教授 (10343831)
Project Period (FY) 2009 – 2011
Keywordsナノバイオ材料 / ウイルス不活化 / 有機無機複合 / 静電気力
Research Abstract

Hydroxyapatite nanocrystals(HAp) with the property of electrical attraction to virus was developed by applying pure HAp at a constant voltage, called as electret HAp(E-HAp). The adsorption properties of fibroblast and baculovirus to pure HAp and E-HAp have no difference ; however, the amount of adsorbed baculovirus to pure HAp was three times higher than that of polystyrene. Inactivation of the adsorbed virus should be needed for the further immobilization of a virus inactivation agency.

  • Research Products

    (40 results)

All 2012 2011 2010 2009 Other

All Journal Article (27 results) (of which Peer Reviewed: 25 results) Presentation (6 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Analytical investigation of protein mediation between biomaterials and cells2012

    • Author(s)
      Tagaya M, Ikoma T, Hanagata N, Tanaka J
    • Journal Title

      Materials Express

      Volume: 2 Pages: 1-22

    • Peer Reviewed
  • [Journal Article] Interfacial serum protein effect on biological apatite growth2011

    • Author(s)
      Tagaya M, Ikoma T, Takeguchi M, Hanagata N, Tanaka J
    • Journal Title

      ournal of Physical Chemistry C

      Volume: 115 Pages: 22523-22533

    • Peer Reviewed
  • [Journal Article] Nano/microstructural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesion2011

    • Author(s)
      Tagaya M, Yamazaki T, Tsuya D, Sugimoto Y, Hanagata N, Ikoma T
    • Journal Title

      Macromolecular Bioscience

      Volume: 11 Pages: 1586-1593

    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Eu(III)-Containing Nanoporous Silicas2011

    • Author(s)
      Tagaya M, Ikoma, T, Yoshioka T, Minami F, Tanaka J
    • Journal Title

      Materials Letters

      Volume: 65 Pages: 2287-2290

    • Peer Reviewed
  • [Journal Article] Effect of interfacial proteins on osteoblast-like cell adhesion to hydroxyapatite nanocrystals2011

    • Author(s)
      Tagaya M, Ikoma T, Takemura T, Hanagata N, Yoshioka T, Tanaka J
    • Journal Title

      Langmuir

      Volume: 27 Pages: 7635-7644

    • Peer Reviewed
  • [Journal Article] Detection of interfacial phenomena with osteoblast-like cell adhesion on hydroxyapatite and oxidized poly(styrene) by quartz crystal microbalance with dissipation2011

    • Author(s)
      Tagaya M, Ikoma T, Takemura T, Hanagata N, Okuda M, Yoshioka T, Tanaka J
    • Journal Title

      Langmuir

      Volume: 27 Pages: 7635-7644

    • Peer Reviewed
  • [Journal Article] Competitive adsorption behavior of fibronectin and albumin on hydroxyapatite nanocrystals2011

    • Author(s)
      Tagaya, M, Ikoma T, Hanagata N, Tanaka J
    • Journal Title

      Science and Technology of Advanced Materials

      Pages: 6015012

    • Peer Reviewed
  • [Journal Article] Hepatocyte adhesion behavior on modified hydroxyapatite nanocrystals with quartz crystal microbalance2011

    • Author(s)
      Tagaya M, Yamazaki T, Migita S, Hanagata N, Ikoma T
    • Journal Title

      Bioceramics Development and Applications

      Volume: 1

    • DOI

      DOI:10.4303/bda/D110157

    • Peer Reviewed
  • [Journal Article] Initial adhesion behavior of fibroblasts onto hydroxyapatite nano-crystals2011

    • Author(s)
      Tagaya M, Ikoma T, Takemura T, Migita S, Okuda M, Yoshioka T, Hanagata N, Tanaka J
    • Journal Title

      Bioceramics Development and Applications

      Volume: Vol.1 Pages: 4

    • Peer Reviewed
  • [Journal Article] Protein Adsorption and Subsequent Fibroblasts Adhesion on Hydroxyapatite Nanocrystals2011

    • Author(s)
      Tagaya M, Ikoma T, Takemura T, Hanagata N, Yoshioka T, Tanaka J
    • Journal Title

      IOP Conference Series : Materials Science and Engineering

      Volume: 18 Pages: 192009

    • Peer Reviewed
  • [Journal Article] Reusable hydroxyapatite nanocrystal sensors for protein adsorption2010

    • Author(s)
      Tagaya T, Ikoma T, Hanagata N, Chakarov D, Kasemo B, Tanaka J
    • Journal Title

      Science and Technology for Advanced Materials

      Volume: 11 Pages: 045002

    • Peer Reviewed
  • [Journal Article] Cartilage regeneration using a porous scaffold, a collagen sponge incorporating a hydroxyapatite/chondroitin sulfate composite2010

    • Author(s)
      Ohyabu Y, Adegawa T, Yoshioka T, Ikoma T, Uemura T, Tanaka J
    • Journal Title

      Materials Science and Engineering B

      Volume: 172 Pages: 204-207

    • Peer Reviewed
  • [Journal Article] Fetal Bovine Serum Adsorption onto Hydroxyapatite Sensor Monitoring by Quartz Crystal Microbalance with Dissipation Technique2010

    • Author(s)
      Tagaya M, Ikoma T, Migita S, Okuda M, Takemura T, Hanagata N, Yoshioka T, Tanaka J
    • Journal Title

      Material Science & Engineering B : Advanced Functional Solid-state Materials

      Volume: 173 Pages: 176-181

    • Peer Reviewed
  • [Journal Article] Thermal expansion of type A carbonate apatite2010

    • Author(s)
      Tonegawa T, Ikoma T, Suetsugu Y, Igawa N, Matsushita Y, Yoshioka T, Hanagata N, Tanaka J
    • Journal Title

      Material Science & Engineering B : Advanced Functional Solid-state Materials

      Volume: 173 Pages: 171-175

    • Peer Reviewed
  • [Journal Article] Structural analysis of hydroxyapatite coating on magnetite nanoparticles using energy filter imaging and electron tomography2010

    • Author(s)
      Okuda M, Takeguchi M, Ruairc OO, Tagaya M, Zhu Y, Hashimoto A, Hanagata N, Schmitt W, Ikoma T
    • Journal Title

      Journal of Electron Microscopy

      Volume: 59(2) Pages: 173-179

    • Peer Reviewed
  • [Journal Article] Crystal structure refinement of A-type carbonate apatite by X-ray powder diffraction2010

    • Author(s)
      Tonegawa T, Ikoma T, Yoshioka T, Hanagata N, Tanaka J
    • Journal Title

      Journal of Materials Science

      Volume: 45(9) Pages: 2419-2426

    • Peer Reviewed
  • [Journal Article] In vivo biological responses and bioresorption of tilapia scale collagen as a potential biomaterial2009

    • Author(s)
      Sugiura H, Yunoki S, Kondo E, Ikoma T, Tanaka J, Yasuda K
    • Journal Title

      Journal of Biomaterials Science

      Volume: 20 Pages: 1353-1368

    • Peer Reviewed
  • [Journal Article] Porous hydroxyapatite and biphasic calcium phosphate ceramic promote ectopic osteoblast differentiation from mesenchymal stem cells2009

    • Author(s)
      Zhang L, Hanagata N, Maeda M, Minowa T, Ikoma T, Fan H, Zhang X
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 10(2) Pages: 025003

    • Peer Reviewed
  • [Journal Article] In situ protein adsorption on different crystal sized hydroxyapatite nanosensors by quartz crystal microbalance with dissipation2009

    • Author(s)
      Ikoma T, Tagaya M, Monkawa A, Hanagta N, Chakarov D, Kasemo B, Tanaka J
    • Journal Title

      ournal of the American Ceramics Society

      Volume: 9(5) Pages: 1125-1128

    • Peer Reviewed
  • [Journal Article] 三次元構造を制御した"骨組織"再生医療向け無機有機複合材料の開発2009

    • Author(s)
      生駒俊之
    • Journal Title

      化学と工業

      Volume: 62 Pages: 540-544

  • [Journal Article] 水酸アパタイト系複合材料の多孔構造とその機能2009

    • Author(s)
      生駒俊之
    • Journal Title

      化学工業

      Volume: 61 Pages: 21-25

  • [Journal Article] Initial adhesion behavior of fibroblasts onto hydroxyapatite nanocrystals2009

    • Author(s)
      Tagaya T, Ikoma T, Takemura T, Migita S, Okuda M, Yoshioka T, Hanagata N, Tanaka J
    • Journal Title

      Key Engineering Materials

      Volume: 51 Pages: 439-442

    • Peer Reviewed
  • [Journal Article] Viscoelastic property of collagen gels with aligned fibril structure2009

    • Author(s)
      Li Y, Hirota M, Okuda M, Chen S, Tagaya M, Shirosaki S, Hayakawa S, Osaka A, Hanagata N, Ikoma T
    • Journal Title

      Key Engineering Materials

      Volume: 51 Pages: 661-664

    • Peer Reviewed
  • [Journal Article] Crystal structure of high purity type A carbonate apatite2009

    • Author(s)
      Tonegawa T, Ikoma T, Suetsugu Y, Igawa N, Matsushita Y, Yoshioka T, Hanagata N, Tanaka J
    • Journal Title

      Key Engineering Materials

      Volume: 51 Pages: 93-96

    • Peer Reviewed
  • [Journal Article] The surface property of hydroxyapatite : Sensing with quartz crystal microbalance2009

    • Author(s)
      Ikoma T, Tagaya M, Tonegawa T, Okuda M, Hanagata N, Yoshioka T, Chakarov D, Kasemo B, Tanaka J
    • Journal Title

      Key Engineering Materials

      Pages: 396-398, 89-92

    • Peer Reviewed
  • [Journal Article] Adsorption of proteins derived from fetal bovine serum onto hydroxyapatite nanocrystals with quartz crystal microbalance technique2009

    • Author(s)
      Tagaya M, Ikoma T, Takemura T, Okuda M, Hanagata N, Yoshioka T, Chakarov D, Kasemo B, Tanaka J
    • Journal Title

      Key Engineering Materials

      Pages: 396-398, 47-50

    • Peer Reviewed
  • [Journal Article] Adsorption and sustained release of insulin from zinc hydroxyapatite microparticle with Poly(lactic acid) coating2009

    • Author(s)
      Tonegawa T, Ikoma T, Yoshioka T, Shinozaki K, Hanagata N, Tanaka J
    • Journal Title

      Key Engineering Materials

      Pages: 396-398, 396-398

    • Peer Reviewed
  • [Presentation] Biomolecular adsorption on apatite nanocrystals monitoring with QCM-D and SPR techniques2010

    • Author(s)
      Ikoma T, Tanaka J and Hanagata N
    • Organizer
      Science and technology for advanced ceramics
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-06-24
  • [Presentation] SPR法を用いた水酸アパタイトナノ結晶表面へのフィブリノーゲンの結合挙動の計測2010

    • Author(s)
      有坂智帆、多賀谷基博、花方信孝、生駒俊之
    • Organizer
      第48回セラミックス基礎討論会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-01-12
  • [Presentation] Initial adhesion behavior of fibroblasts onto hydroxyapatite nanocrystals2009

    • Author(s)
      Tagaya T, Ikoma T, Takemura T, Migita S, Okuda M, Yoshioka T, Hanagata N, Tanaka J
    • Organizer
      22th International Symposium of Ceramics in Medicine
    • Place of Presentation
      Degu
    • Year and Date
      2009-10-21
  • [Presentation] Crystal structure of high purity type A carbonate apatite2009

    • Author(s)
      Tonegawa T, Ikoma T, Suetsugu Y, Igawa N, Matsushita Y, Yoshioka T, Hanagata N, Tanaka J
    • Organizer
      22th International Symposium of Ceramics in Medicine
    • Place of Presentation
      Degu
    • Year and Date
      2009-10-21
  • [Presentation] Hepatocyte adhesion behavior on modified hydroxyapatite nanocrystals with quartz crystal microbalance2009

    • Author(s)
      Ikoma T, Tagaya M, Yamazaki T, Migita S, Hanagata N
    • Organizer
      22th International Symposium of Ceramics in Medicine
    • Place of Presentation
      Degu
    • Year and Date
      2009-10-21
  • [Presentation] In situ analysis of interfacial interaction between cells and biomaterials by using quartz crystal microbalance with dissipation technique2009

    • Author(s)
      Ikoma T, Tagaya M, Yamazaki T, Hanagata N
    • Organizer
      8th International symposium on frontiers in biomedical polymers
    • Place of Presentation
      Mishima
    • Year and Date
      2009-05-27
  • [Book] 生体調和機能-生体と調和するセラミックス・アパタイト系バイオミネラル(総論)2011

    • Author(s)
      田中順三、生駒俊之
    • Total Pages
      371-375
    • Publisher
      株式会社エヌ・ティー・エス(東京都文京区)
  • [Book] 生体分子を認識・吸着するセラミックスーアパタイト系・表面界面2011

    • Author(s)
      生駒俊之、多賀谷基博、吉岡朋彦、田中順三
    • Total Pages
      382-390
    • Publisher
      株式会社エヌ・ティー・エス(東京都文京区)
  • [Book] ハイドロキシアパタイト、骨粗鬆症治療2011

    • Author(s)
      早乙女進一、生駒俊之
    • Total Pages
      149-151
  • [Book] バイオセラミックス2009

    • Author(s)
      田中順三、生駒俊之、植村寿公、大森健一
    • Publisher
      コロナ社
  • [Book] バイオマテリアルにおける有機無機界面の創製と機能発現2009

    • Author(s)
      生駒俊之、田中順三
    • Total Pages
      335-344
    • Publisher
      株式会社シーエムシー出版(東京都千代田区)
  • [Book] セラミックスの事典、II焼結体2009

    • Author(s)
      生駒俊之、田中順三
    • Total Pages
      118-119
    • Publisher
      朝倉書店(東京都新宿区)
  • [Remarks]

    • URL

      http://www.bio.ceram.titech.ac.jp/

URL: 

Published: 2013-07-31  

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