2012 Fiscal Year Final Research Report
Patho-mechanism ofdegenerated disc disorders of lumbar spine and development of the minimally invasive treatment system
| Project/Area Number |
21300189
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kobe University |
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Principal Investigator |
NISHIDA Kotaro 神戸大学, 医学部附属病院, 講師 (00379372)
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| Co-Investigator(Kenkyū-buntansha) |
DOITA Minoru 神戸大学, 医学研究科, 医学研究員 (60237170)
MAENO Koichiro 神戸大学, 医学研究科, 助教 (70403269)
KAKUTANI Kenichiro 神戸大学, 医学部附属病院, 助教 (10533739)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 低侵襲治療システム |
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| Research Abstract |
Low back pain and associated spinal disorders including lumbardisc herniation (LDH) and lumbar spinal-canal stenosis (LSS) are formidable problems for society. In this study, we
1) established animal model of disc degeneration and investigated the significant factors for progressive disc degeneration, and developed a new strategy against degenerated disc;
2) developed and modified the novel implant which enable us for minimally invasive surgery against LSS patients;
3) developed LDH animal model and obtained useful data by analyzing this model, that can be potentially used for the new treatment for LDH patients.
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[Journal Article] Matrix metalloproteinase (MMP)-3 gene up-regulation in a rat tail compression loading-induced disc degeneration model.2010
Author(s)
Yurube T, Nishida K,Suzuki T, Kaneyama S, Zhang Z, Kakutani K, MaenoK, Takada T, Fujii M, Kurosaka M, Doita M
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Journal Title
J Orthop Res
Volume: 28(8)
Pages: 1026-1032
Peer Reviewed
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[Presentation] Actin-beta should not be used as an endogenous control in real-time RT-PCR for intervertebral disc research under mechanical loading stress condition2010
Author(s)
Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
Organizer
37th International Society for the Study of the Lumbar Spine (ISSLS)
Place of Presentation
Auckland, New Zealand
Year and Date
20100413-17
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[Presentation] Activated apoptotic mitochondrial pathway in a rat tail compression loading-induced disc degeneration model2010
Author(s)
Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
Organizer
37th ISSLS
Place of Presentation
Auckland, New Zealand
Year and Date
20100413-17
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[Presentation] Imbalanced catabolic relative to anabolic gene alterations in a rat tail compression loading-induced disc degeneration model.2010
Author(s)
Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamono J, Kakutani K, Maeno K, Takada T, Iguchi T, Kurosaka M, Doita M
Organizer
37th ISSLS
Place of Presentation
Auckland, New Zealand
Year and Date
20100413-17
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[Presentation] Imbalanced catabolic and anabolic gene alterations in a rat tail compression loading-induced disc degeneration model2010
Author(s)
Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamoto J, Kakutani K, Maeno K, Takada T, Kurosaka M, Doita M
Organizer
56th Orthopaedic Research Society(ORS)
Place of Presentation
New Orleans, USA
Year and Date
20100306-09
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[Presentation] Activated mitochondrial pathway of apoptosis in a rat tail compression loading-induced disc degeneration model2010
Author(s)
Yurube T, Nishida K, Suzuki T, Zhang Z, Yamamoto J, Kakutani K, Maeno K, Takada T, Kurosaka M, Doita M
Organizer
56th ORS
Place of Presentation
New Orleans, USA
Year and Date
20100306-09
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