Experimental rehabilitation on rodents hemiplegia

2011 Fiscal Year Final Research Report

• Project/Area Number: 21300199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KUMEI Yasuhiro 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (30161714)
• Co-Investigator(Kenkyū-buntansha): OJIMA Hisayuki 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (00104539) ; ISHIDA Takayoshi 東京医科歯科大学, 歯学部附属病院, 医員 (90549966)
• Co-Investigator(Renkei-kenkyūsha): JORGE Zeredo 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (10363459) ; INOUE Ka 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90302877) ; AOU Shuji 九州工業大学, 大学院・生命体工学研究科, 教授 (40150908) ; HASEGAWA Katsuya 宇宙航空研究開発機構, 宇宙科学研究所, 開発員 (30425780)
• Project Period (FY): 2009 – 2011
• Keywords: 片麻痺 / リハビリテーション / ニューロン活動 / 行動 / 高次脳機能

Research Abstract

We studied on various experimental rehabilitation using rodent hemiplegia models. X-ray analysis provides more significant detailed information about moving/behavior and its regulation on the joint-skeletal system of animals. Pain sensation makes a good indicator that reflects the recovery process of hemiplegia so as to prospect a reliable rehabilitation model. We succeeded for the first time in dual measurement of electrophysiological and neurochemical activities of the CNS that controls behavior/moving of rodents. These brain areas respond positively and negatively to mechanical loading and unloading. An appropriate mechanical loading enhances efficiency of synaptic transmission in hippocampus and amygdala that reflects stimulated function of learning/memory and emotional response. These molecular-based approaches would contribute to new rehabilitation for hemiplegia.

Research Products

• [Presentation] Posture, Behavior, and Neuronal Activity in Partial Gravity (2011)
  • Author(s): Y. Kumei, K. Hasegawa, J. L. Zeredo, K. Narikiyo, K. A. Inoue, Y. Watanabe, Y. Maezawa, N. Ishioka, M. Yamashita, and S. Aou : Rodents Response to Lunar and Martian Gravity
  • Organizer: 27^<th> annual meeting, ASGSB
  • Place of Presentation: San Jose
  • Year and Date: 2011-11-03
• [Presentation] Japanese Research Group for Animal and Human Physiology in Lunar and Martian Gravity (2009)
  • Author(s): Y. Kumei, J. L. Zeredo, T. Yabushita, T. Ishida, S. Seki, T. Ikeda, K. Toda, M. Matsuura, Y. Nomura, K. Iwasaki, F. Kawano, Y. Ohira, M. Okuno, D. Kageyama, and M. Yamashita
  • Organizer: 25^<th> annual meeting, ASGSB
  • Place of Presentation: Raleigh
  • Year and Date: 2009-11-07
• [Presentation] Nociceptive behaviors in rats at low gravity conditions (2009)
  • Author(s): T. Ishida, J. L. Zeredo, T. Yabushita, S. Seki, Y. Fusejima, G. Fukushima, K. Toda, Y. Kumei
  • Organizer: Congress Pain
  • Place of Presentation: Lisbon
  • Year and Date: 2009-09-10