2011 Fiscal Year Final Research Report
Investigation for the mechanism of joint contracture and the effect of rehabilitation based on comprehensive analysis concerning surrounding tissue of joint
| Project/Area Number |
21300200
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
OKITA Minoru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50244091)
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| Co-Investigator(Kenkyū-buntansha) |
ORIGUCHI Tomoki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90295105)
NAKANO Jiro 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20380834)
SAKAMOTO Jyunya 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20584080)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Jyunya 長崎大学病院, リハビリテーション部, 理学療法士 (20584080)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 障害学 / 拘縮 / 骨格筋 / 皮膚 / 関節包 / コラーゲン / 線維化 / TGF-β / 筋線維芽細胞 |
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| Research Abstract |
Clinically, the contracture that is one of the functional disorders is often caused by immobilization of a joint with a plastic cast etc, however, this mechanism is not yet clear. The objective of this study is to clarify the mechanism of contracture based on comprehensive analysis concerning surrounding tissue of joint in experimental animal model. Our results suggest that the molecular mechanism of immobilization-induced muscle fibrosis relate the cytokine signal by TGF-βis activated, the differentiation from the fibroblast to myofibroblast is accelerated, and the type I and III collagen increase. Additionally, the immobilization-induced muscle fibrosis may progress by a decrease in mechanical stimulation. Immobilization of the joint causes the fibrosis of the synovial membrane and the tissue under the skin. There is an important relation in the mechanism because the contracture progresses by these changes.
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[Journal Article] Immobilization-induced cartilage degeneration mediated through expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and chondromodulin-I2009
Author(s)
Sakamoto J, Origuchi T, Okita M, Nakano J, Kato K, Yoshimura T, Izumi S, Komori T, Nakamura H, Ida H, Kawakami A, Eguchi K
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Journal Title
Connect Tissue Res
Volume: 50
Pages: 37-45
Peer Reviewed
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[Presentation] 不動に伴うラット軟骨基質の変化,ならびに持続的他動運動の影響2009
Author(s)
坂本淳哉, 坂井孝行, 折口智樹, 中野治郎, 片岡英樹, 西川正悟, 近藤康隆, 横山真吾, 江口勝美, 沖田実
Organizer
第44回日本理学療法学術大会
Place of Presentation
東京
Year and Date
20090528-30
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