Neuronal and biological bases of the motivation in rehabilitation

2011 Fiscal Year Final Research Report

• Project/Area Number: 21300205
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: ONOE Hirotaka 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, チームリーダー (80214196)
• Co-Investigator(Kenkyū-buntansha): TAHARA Tsuyoshi 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (20419708) ; YAMANAKA Hajime 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, リサーチアソシエイト (10415573)
• Co-Investigator(Renkei-kenkyūsha): ISA Tadashi 生理学研究所, 発達生理学研究系, 教授 (20212805) ; NISHIMURA Yukio 生理学研究所, 発達生理学研究系, 准教授 (20390693)
• Project Period (FY): 2009 – 2011
• Keywords: 脊髄損傷 / リハビリテーション / 側坐核 / モチベーション / PET / 脳機能イメージング

Research Abstract

Here, we show that activity of the ventral striatum, including the nucleus accumbens(NAc), which plays a critical role in processing of motivation, increased and its functional connectivity with M1 emerged and was progressively strengthened during the recovery. In addition, functional connectivities among M1, the ventral striatum and other structures belonging to neural circuits for processing motivation were also strengthened during the recovery. In addition, lesion of NAc by ibotenic acid prior to spinal cord injury resulted in the delay of recovery. These results give clues to the neuronal substrate for motivational regulation of motor learning required for functional recovery after spinal-cord injury.

Research Products

• [Journal Article] Cortical and subcortical compensatory mechanisms after spinal cord injury in monkeys (2012)
  • Author(s): Nishimura Y, Isa T
  • Journal Title: Experimental Neurology, Special Issue "Plasticity after spinal cord injury"(review) Volume: 235 Pages: 152-61
  • Peer Reviewed
• [Journal Article] Neural substrate for motivational regulation of motor recovery after spinal-cord injury (2011)
  • Author(s): Nishimura Y, Onoe H, Onoe K, Morichika Y, Tsukada H, Isa T
  • Journal Title: PLoS One Volume: 6(9) Pages: 24854
  • Peer Reviewed
• [Journal Article] Compensatory changes at the cerebral cortical level after spinal cord injury (2009)
  • Author(s): Nishimura Y, Isa T
  • Journal Title: The Neuroscientist(review) Volume: 15 Pages: 436-444
  • Peer Reviewed
• [Presentation] 脊髄損傷後の運動機能回復戦略 (2012)
  • Author(s): 西村幸男
  • Organizer: 第89回日本生理学大会
  • Place of Presentation: 長野
  • Year and Date: 20120329-31
• [Presentation] 脊髄損傷サルにおける一次運動野手指制御領域から脊髄への軸索投射の定性的及び定量的解析 (2010)
  • Author(s): 吉野紀美香、西村幸男、大石高生、伊佐正
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 20100902-04
• [Presentation] Area-specific regulation of gene expression in monkey motor cortices during recovery from spinal-cord injury (2010)
  • Author(s): Sato A, Higo N, Oishi T, Nishimura Y, Yamamoto T, Murata Y, Saito-Yoshino K, Tsuboi F, Takahashi M, Onoe H, Isa T, Kojima T
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 20100902-04
• [Presentation] Effect of early rehabilitative training after spinal cord lesion in macaque monkeys (2010)
  • Author(s): Sugiyama Y, Higo N, Saito-Yoshino K, Murata Y, Nishimura Y, Oishi T, Isa T
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 20100902-04
• [Remarks]
  • URL: http://www.riken.jp/r-world/info/release/news/2012/apr/frol_02.html