2011 Fiscal Year Final Research Report
Does pentraxin 3 participate in the mechanism underlying habitual aerobic exercise-induced increase in arterial distensibility?
| Project/Area Number |
21300234
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MAEDA Seiji 筑波大学, 体育系, 講師 (30282346)
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| Co-Investigator(Kenkyū-buntansha) |
AJISAKA Ryuichi 筑波大学, 体育系, 教授 (70151058)
TANAKA Kiyoji 筑波大学, 体育系, 教授 (50163514)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 有酸素性運動 / 動脈伸展性 / ペントラキシン3 / 抗炎症作用 / 加齢 / 肥満 / 心血管疾患 |
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| Research Abstract |
Aging and/or obesity induce the decrease in arterial distensibility. Reduction in arterial distensibility is believed to contribute to the pathophysiology of cardiovascular disease and has been identified as a powerful and independent risk factor for cardiovascular disease. On the other hand, habitual aerobic exercise results in a significant increase in arterial distensibility. However, it is unclear the mechanism underlying habitual aerobic exercise-induced enhancement of arterial distensibility. The present study was to investigate whether pentraxin 3 (PTX3), anti-inflammatory protein, is involved in the mechanism underlying the increase in arterial distensibility with aerobic exercise training. We suggest that PTX3 may be an important mechanism underlying the beneficial effect of aerobic exercise training on arterial distensibility.
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Research Products
(6 results)
