2012 Fiscal Year Final Research Report
BIO-IMAGING OF SATELLITE CELL IN REGENERATING MUSCLE
| Project/Area Number |
21300236
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Aichi University of Education |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MACHIDA Syuichi 東海大学, 体育学部, 准教授 (40421226)
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| Research Collaborator |
ISHIDO Minenori 愛知教育大学, 教育学部, 研究補佐員
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| Project Period (FY) |
2009 – 2012
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| Keywords | スポーツ生理学 / 再生筋 |
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| Research Abstract |
The recruitment of satellite cells, which are located between the basement membrane and the plasma membrane in myofibers, is controlled by muscle injury or overload, several growth factor. It is poorly understood how the satellite cell migration is involved in muscle regeneration after injury because in vivo it has been technically very difficult to visualize the living satellite cells localized. In the present study, by using quantum dots conjugated with an anti-M-cadherin antibody, we first demonstrated that the satellite cell migration toward the injured site was induced in the injured muscles, and toward the end of myofibers in early developing stage muscle. Thus, it was suggested that the satellite cell migration may be play important roles to regulate the muscle regeneration and development.
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