2011 Fiscal Year Final Research Report
Mechanisms of increase in exercise induced energy expenditure
| Project/Area Number |
21300240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | National Institute of Health and Nutrition |
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Principal Investigator |
MIURA Shinji 独立行政法人国立健康・栄養研究所, 基礎栄養研究部脂質・糖代謝研究室, 室長 (10342932)
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| Co-Investigator(Renkei-kenkyūsha) |
EZAKI Osamu 独立行政法人国立健康・栄養研究所, 基礎栄養研究部, 部長 (90191923)
KAMEI Yasutomi 東京医科歯科大学, 難治疾患研究所, 特任教授 (70300829)
KANO Yutaka 電気通信大学, 情報理工学部, 准教授 (90293133)
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| Project Period (FY) |
2009 – 2011
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| Keywords | エネルギー代謝 |
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| Research Abstract |
Trained subjects have a high VO2max due to a high cardiac output and high metabolic capacity of skeletal muscles. Because exercise training increases peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α) in skeletal muscle, PGC-1α-mediated changes may contribute to the improvement of exercise capacity and VO2max. There are three isoforms of PGC-1αmRNA. PGC-1α-b protein is a predominant PGC-1αisoform in response to exercise. In this study, we showed that PGC-1α-b induced increased mitochondrial biogenesis, capillaries, and fatty acid transporters in skeletal muscles may contribute to improved exercise capacity via an increase in fatty acid utilization.
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Research Products
(25 results)
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[Journal Article] Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake2011
Author(s)
Tadaishi, M., Miura, S., Kai, Y., Kano, Y., Oishi, Y., and Ezaki, O.
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Journal Title
PLoS ONE
Volume: 6(12)
Pages: e28290
URL
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[Journal Article] Control of microvascular PO2 kinetics following onset of muscle contractions : Role for AMPK2011
Author(s)
Kano, Y., Poole, D. C., Sudo, M., Hirachi, T., Miura, S., and Ezaki, O.
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Journal Title
Am. J. Physiol. Regul. Integr. Comp. Physiol
Volume: 301
Pages: R1350-R1357
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[Journal Article] Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1αmRNA : a role ofβ2-adrenergic receptor activation2011
Author(s)
Tadaishi, M., Miura, S., Kai, Y., Kawasaki, E., Koshinaka, K., Kawanaka, K., Nagata, J., Oishi, Y., and Ezaki, O.
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Journal Title
Am. J. Physiol. Endocrinol. Metab
Volume: 300
Pages: E341-E349
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[Journal Article] Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle2009
Author(s)
Setsuie, R., Suzuki, M., Kabuta, T., Fujita, H., Miura, S., Ichihara, N., Yamada, D., Wang, YL., Ezaki, O., Suzuki, Y., and Wada, K.
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Journal Title
FASEB J
Volume: 23
Pages: 4148-4157
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[Journal Article] α2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise2009
Author(s)
Miura, S., Kai, Y., Kamei, Y., Bruce, C. R., Kubota, N., Febbraio, M. A., Kadowaki, T., and Ezaki, O.
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Journal Title
Am. J. Physiol. Endocrinol. Metab
Volume: 296
Pages: E47-E55
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