2011 Fiscal Year Final Research Report
Effects of exercise and food restriction during childhood on the set point for body weight in genetically obese OLETF rats
| Project/Area Number |
21300256
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
SUZUKI Masato 東京慈恵会医科大学, 医学部, 教授 (10110925)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Hideki 東京慈恵会医科大学, 医学部, 講師 (60220224)
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| Co-Investigator(Renkei-kenkyūsha) |
MACHIDA Shuichi 東海大学, 体育学部, 准教授 (40421226)
KIMURA Masaki 慶應義塾大学, 薬学部, 講師 (40383666)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 体重セットポイント / 幼若齢期 / 運動 / 給餌制限 / 体重 / 除脂肪量 / UCP-3mRNA |
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| Research Abstract |
The present study was conducted to examine whether a decrease in energy expenditure caused by reduced physical activity during childhood or an increase in energy intake caused by overeating during childhood was responsible for resetting the set point for body weight(BW). At the completion of the experiment, lean body mass(LBM); energy metabolism-related enzymes such as CS, SDH, and PFK ; and UCP-3mRNA expression were significantly higher in the exercise group than in the diet-restriction and sedentary groups. The present study suggests that prevention of BW gain by performing regular exercise during childhood contributes to increased skeletal muscle mass and enhanced energy expenditure. Further, early-onset exercise may contribute to resetting the set point for BW in individuals genetically predisposed to obesity.
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