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2011 Fiscal Year Final Research Report

Nutritional functions and its organ metabolism network

Research Project

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Project/Area Number 21300277
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

TAKEDA Eiji  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00144973)

Co-Investigator(Kenkyū-buntansha) TAKETANI Yutaka  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30263825)
Project Period (FY) 2009 – 2011
Keywords栄養素 / 相互作用 / パラチノース / オレイン酸 / 線維芽細胞増殖因子21(FGF21)
Research Abstract

In this research, it is clarified that synergistic effects of combination of palatinose and oleic acid or sucrose and linolic acid are explained by changes of fatty acid components in various organs and that fibroblast growth factor 21 is an important metabolically protective factor because increased expression is observed in both hunger and satiety stimuli.

  • Research Products

    (30 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (17 results) Book (1 results)

  • [Journal Article] Protective Effects of Dipeptidyl Peptidase-4(DPP-4) Inhibitor against Increased2011

    • Author(s)
      Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y
    • Journal Title

      Cell Apoptosis Induced by Dietary Sucrose and Linoleic Acid in Mice with Diabetes.

      Volume: 286(29) Pages: 25467-25476

    • DOI

      DOI:10.1074/jbc.M110.217216

    • Peer Reviewed
  • [Journal Article] Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity2011

    • Author(s)
      Taniguchi-Fukatsu A, Yamanaka-Okumura H, Naniwa-Kuroki Y, Nishida Y, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance

      Volume: 7 Pages: 1-8

    • DOI

      DOI:10.1017/s0007114511004156

    • Peer Reviewed
  • [Journal Article] Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet2011

    • Author(s)
      Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M, Yamanaka-Okumura H, Takeda E
    • Journal Title

      J Nutr Biochem

    • DOI

      DOI:10.1016/j.jnutbio.2011.03.023

    • Peer Reviewed
  • [Journal Article] Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals : Is FGF21 a Nutritional Adaptation Factor?2011

    • Author(s)
      Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
    • Journal Title

      PLoS One

      Volume: 6(8) Pages: e22976

    • DOI

      DOI:10.1371/journal.pone.0022976

    • Peer Reviewed
  • [Journal Article] Effects of xylitol on metabolic parameters and visceral fat accumulation2011

    • Author(s)
      Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      J Clin Biochem Nutr

      Volume: 49(1) Pages: 1-7

    • DOI

      DOI:10.3164/jcbn.10-111

    • Peer Reviewed
  • [Journal Article] Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice2011

    • Author(s)
      Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y
    • Journal Title

      Diabetes

      Volume: 60 Pages: 1246-1257

    • DOI

      DOI:10.2337/db10-1338

    • Peer Reviewed
  • [Journal Article] Increasing early insulin secretion compensate adequately for hepatic insulin resistance in CCI4-induced cirrhosis rats2010

    • Author(s)
      Arai H, Awane N, Mizuno A, Fukaya M, Sakuma M, Harada N, Kawaura A, Yamamoto H, Okumura H, Taketani Y, Doi T, Takeda E
    • Journal Title

      The Journal of Medical Investigation

      Volume: 57(1-2) Pages: 54-61

    • DOI

      10.2152/jmi.57.54

    • Peer Reviewed
  • [Journal Article] Effect of long-term late-evening snack on health-related quality of life in cirrhotic patients2010

    • Author(s)
      Yamanaka-Okumura H, Nakamura T, Miyake H, Takeuchi H, Katayama T, Morine Y, Imura S, Shimada M, Takeda E
    • Journal Title

      Hepatology Research

      Volume: 40(5) Pages: 470-476

    • DOI

      DOI:10.111/j.1872-034X.2010.00637.x

    • Peer Reviewed
  • [Journal Article] Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury2010

    • Author(s)
      Shiota A, Hada T, Baba T, Sato M, Yamanaka-Okumura H, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      J Med Invest

      Volume: 57(3, 4) Pages: 314-320

    • DOI

      10.2152/jmi.57.314

    • Peer Reviewed
  • [Journal Article] Does-dependent Effects of Barley Cooked with White Rice on postprandial Glucose and Desacyl Ghrelin Levels2009

    • Author(s)
      Sakuma M, Yamanaka-Okumura H, Naniwa Y, Matsumoto D, Tsunematsu M, Yamamoto H, Taketani Y, Takeda E
    • Journal Title

      J Clin Biochem Nutr

      Volume: 44(2) Pages: 151-159

    • DOI

      10.3164/jcbn.08-232

    • Peer Reviewed
  • [Journal Article] Improvement of Glucose Metabolism in Patients with Impaired Glucose Tolerance or Diabetes by Long-Term Administration of a Palatinose-Based Liquid Formula as a Part of Breakfast2009

    • Author(s)
      Sakuma M, Arai H, Mizuno A, Fukaya M, Matsuura M, Sasaki H, Yamanaka-Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E
    • Journal Title

      J Clin Biochem Nutr

      Volume: 45 Pages: 155-162

    • DOI

      10.3164/jcbn.09-08

    • Peer Reviewed
  • [Journal Article] Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways2009

    • Author(s)
      Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Amo K, Harada N, Arai H, Yamamoto H, Takeda E
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 297 Pages: E76-E84

    • DOI

      DOI:10.1152/ajpendo.00014.2009

    • Peer Reviewed
  • [Presentation] 食餌中の糖・脂質の異なる組合せがZucker fattyラットのインスリン感受性と骨格筋の脂肪酸組成に及ぼす影響2012

    • Author(s)
      大南博和、阿望幾久子、竹谷豊、佐藤佳瑞智、新井英一、小金井恵、佐々木一、奥村仙示、山本浩範、武田英二
    • Organizer
      第15回日本病態栄養学会
    • Place of Presentation
      京都国際会議場、京都市
    • Year and Date
      20120114-15
  • [Presentation] Flavonoid Derivatives Prevent Disuse Muscle Atrophy2011

    • Author(s)
      Mukai R, Kawamura T, Nemoto H, Nikawa T, Yamamoto H, Takeda E, Terao J
    • Organizer
      The International Conference on Food Factors 2011
    • Place of Presentation
      Taipei International Convention Center,台北、台湾
    • Year and Date
      20111120-23
  • [Presentation] ヒトFGF21は絶食・飽食シグナルを感知する栄養代謝の変化に応答する因子である2011

    • Author(s)
      竹谷豊、上番増喬、大南博和、武田英二
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路夢舞台会議場、兵庫県
    • Year and Date
      20110923-24
  • [Presentation] Natto And Viscous Vegetables Improved Insulin Sensitivity, Lipid Metabolism and Oxidative Stress in Impaired Glucose Tolerance Subjects 7^<th> APCCN 20112011

    • Author(s)
      Takeda E, Taniguchi-Fukatsu A, Naniwa-Kuroki Y, Nishida Y, Yamamoto H, Taketani Y, Yamanaka-Okumura H
    • Organizer
      the Sofitel Centara Grand Bangkok
    • Place of Presentation
      バンコク、タイ
    • Year and Date
      20110605-09
  • [Presentation] 組織の脂肪酸組成に対して食餌性糖・脂質の組合せが与える影響と、インスリン抵抗性への関連性2011

    • Author(s)
      大南博和、阿望幾久子、竹谷豊、上番増喬、佐藤佳瑞智、深谷牧子、新井英一、小金井恵、佐々木一、山本浩範、武田英二
    • Organizer
      第53回日本糖尿病学会学術集会
    • Place of Presentation
      岡山コンベンションセンター、岡山市
    • Year and Date
      20110527-29
  • [Presentation] パラチノースとオレイン酸の組合せ食による肥満モデルラットの糖・脂質代謝異常抑制効果2010

    • Author(s)
      山本浩範、佐々木一、武田英二
    • Organizer
      第41回日本消化吸収学会総会・第18回日本消化器関連学会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      20101013-16
  • [Presentation] IDENTIFICATION OF LABORATORY BIOMARKER REFLECTING NON PROTEIN RESPIRATORY QUOTIENT(NPRQ) IN HEPATIC CIRRHOSIS2010

    • Author(s)
      Yamanaka-Okumura H, Yamauchi R, Urano E, Katayama T, Imura S, Utsunomiya T, Shimada M, Takeda E
    • Organizer
      32nd ESPEN Congress
    • Place of Presentation
      the Nice Acropolis Congress and Exhibition Centre,ニース、フランス
    • Year and Date
      20100905-08
  • [Presentation] GENE EXPRESSION PROFILING OF HUMAN PERIPHERAL BLOOD IS AFFECTED BY THE DIFFERENCES IN GLYCEMIC AND INSULINEMIC RESPONSES TO FOOD INTAKE2010

    • Author(s)
      Kawakami Y, Yamanaka-Okumura H, Sakuma M, Matsumoto Y, Sato T, Takeda E
    • Organizer
      32nd ESPEN Congress
    • Place of Presentation
      the Nice Acropolis Congress and Exhibition Centre,ニース、フランス
    • Year and Date
      20100905-08
  • [Presentation] Human FGF21 is Paradoxically Induced by both Fasting and Over-Feeding Signals-Is FGF21 a Nutritional Adaptation Factor?.2010

    • Author(s)
      Uebanso T, Taketani Y, Yamamoto H, Amo K, Arai H, Takei Y, Masuda M, Tanimura A, Yamanaka-Okumura H, Takeda E
    • Organizer
      American Diabetes Association(ADA) 70th Annual Scientific Sessions
    • Place of Presentation
      Orange Country Convention Center,オーランド、アメリカ合衆国
    • Year and Date
      20100625-29
  • [Presentation] The Interaction of Dietary Carbohy drate and Fat on Pancreatic Islet Dysfunction Mediated by Glucolipotoxicity2010

    • Author(s)
      Amou K, Ominami H, Taketani Y, Sato K, Fukaya M, Uebanso T, Arai H, Koganei M, Sasaki H, Yamamoto H, Takeda E
    • Organizer
      American Diabetes Association(ADA) 70th Annual Scientific Sessions
    • Place of Presentation
      Orange Country Convention Center,オーランド、アメリカ合衆国
    • Year and Date
      20100625-29
  • [Presentation] Combined Efects of Dietary Carbohy drate and Fat on Tissue Fatty Acid Composition and Insulin Resistance、American Diabetes Association(ADA) 70th Annual Scientific Sessions2010

    • Author(s)
      Ominami H, Amou K, Taketani Y, Uebanso T, Sato K, Fukaya M, Arai H, Koganei M, Sasaki H, Yamamoto H, Takeda E
    • Organizer
      American Diabetes Association(ADA) 70th Annual Scientific Sessions
    • Place of Presentation
      Orange Country Convention Center,オーランド、アメリカ合衆国
    • Year and Date
      20100625-29
  • [Presentation] Increased. Cell Apoptosis with Multiorgan Glucolopotoxicity by a Combination of Dietary Suger and Fatty Acid and Protectiove Effects of DPP-4 Inhibitor Des-Fluoro-Sitagliptin Against Them2010

    • Author(s)
      Shirakawa J, Takeda E, Terauchi Y
    • Organizer
      American Diabetes Association(ADA) 70th Annual Scientific Sessions
    • Place of Presentation
      Orange Country Convention Center,オーランド、アメリカ合衆国
    • Year and Date
      20100625-29
  • [Presentation] 糖・脂肪毒性の相互作用を介した膵β細胞障害の発症機序の解明2010

    • Author(s)
      阿望幾久子、大南博和、竹谷豊、佐藤佳瑞智、深谷牧子、上番増喬、新井英一、小金井恵、佐々木一、山本浩範、武田英二
    • Organizer
      第53回日本糖尿病学会学術集会
    • Place of Presentation
      岡山コンベンションセンター、岡山市
    • Year and Date
      20100527-29
  • [Presentation] 肝疾患患者に対するテーラーメイド栄養管理の血液生化学指標についての検討2010

    • Author(s)
      奥村仙示、山内利香、浦野恵利、居村暁、宇都宮徹、島田光生、武田英二
    • Organizer
      第33回日本栄養アセスメント研究会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪府
    • Year and Date
      20100514-15
  • [Presentation] FGF21はグルコースにより誘導される2010

    • Author(s)
      上番増喬、竹谷豊、山本浩範、阿望幾久子、新井英一、竹井悠一郎、増田真志、谷村綾子、原田永勝、奥村仙示、武田英二
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都国際会議場、京都市
    • Year and Date
      20100109-10
  • [Presentation] Hypocaloric Carbohydrate Restricted Diet Improves Fatty Liver and Hypertriglyceridemia in Sucrose-fed Obese Rats via Two Pathways2009

    • Author(s)
      Uebanso T, Taketani Y, Fukaya M, Sato K, Takei Y, Sato T, Sawada N, Amo K, Arai H, Harada N, Yamamoto H, Takeda E
    • Organizer
      American Diabetes Association 69th Scientific Sessions
    • Place of Presentation
      Memorial Convention Center,ニューオーリンズ、アメリカ合衆国
    • Year and Date
      20090605-09
  • [Presentation] 低エネルギー高タンパク食は肥満ラットにおいて2つの経路を介して脂肪肝、高TG血症を改善する2009

    • Author(s)
      上番増喬、竹谷豊、深谷牧子、佐藤佳瑞智、阿望幾久子、新井英一、奥村仙示、山本浩範、武田英二
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20090521-24
  • [Book] メタボリックシンドローム、第8章各疾患の栄養管理、キーワードでわかる臨床栄養改訂版栄養で治す!基礎から実践まで2011

    • Author(s)
      武田英二、池田翔子、香西美奈
    • Publisher
      株式会社羊土社

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Published: 2013-07-31  

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