2013 Fiscal Year Final Research Report
Formulation of the rare sugar delivery system for functional food and the safety assessment method
| Project/Area Number |
21300282
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
SHIRAI Yoko 独立行政法人物質・材料研究機構, 生体機能材料ユニット, 主幹エンジニア (10399404)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Nobuhiro 東北大学, 歯学研究科, 教授 (60183852)
KAMIMURA Wataru 東京大学, 医学部付属病院, 研究員 (80399394)
KANETAKA Hiroyasu 東北大学, 歯学研究科, 准教授 (50292222)
SHIMIZU Yoshinaka 東北大学, 歯学研究科, 助教 (30302152)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Tatsuhiro 香川大学, 農学部, 教授 (20270019)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 希少糖 / DDS / 安全性評価 |
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| Research Abstract |
Although it has been difficult to supply a large amount of rare sugars, an inexpensive synthetic method on a large scale was recently established, leading to the reports on various physiological functions including regulation of blood glucose level and suppression of body fat accumulation. Meanwhile, it has been pointed out that rare sugars are difficult to utilize as foodstuffs by reason that they are excreted after the gut absorption more rapidly than typical monosaccharide.
Therefore in present study, by applying drug delivery systems (DDS), we tried to bring the physiological functions of rare sugars into action efficiently by means of improving the stability in the body and prolonging the residence time. In addition, safety assessment methods for functional foods containing saccharides such as those exerted in the oral cavity were examined.
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