2011 Fiscal Year Final Research Report
Biological functions of polyphenols-Search for their bindingfactors and mechanism in the binding
| Project/Area Number |
21310045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kwansei Gakuin University |
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Principal Investigator |
IMAOKA Susumu 関西学院大学, 理工学部, 教授 (60145795)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Kazushi 関西学院大学, 理工学研究科, 博士研究員 (40423892)
KATSUMURA Shigeo 関西学院大学, 理工学部, 教授 (70047364)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ビスフェノール / レスベラトロール / プロテインジスルフィドイソメラーゼ / 甲状腺ホルモン応答 / 低酸素応答 |
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| Research Abstract |
We found that polyphenols such as bisphenol A (BPA) and resveratrol (RES) inhibited the hypoxic response of the cells (Hep3B cells) and that BPA enhanced the T3-response of the cells (GH3 cells). However, the mechanism of these phenomena was not still understood. We already found that BPA bounds to protein disulfide isomerase (PDI) and inhibits its activity. In this study, we found that PDI regulated the redox state of T3 receptor via Ref-1 which was originally found as redox factor of HIF-1α, the key regulator of hypoxic response. These findings suggest that PDI regulates the redox states of nucleus factors and poly phenol may affect the activation of nucleus factors by inhibition of PDI.
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