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2011 Fiscal Year Final Research Report

Study of membrane-linked signaling pathways for evaluation of estrogenic chemicals

Research Project

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Project/Area Number 21310046
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

KIYAMA Ryoiti  独立行政法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (00240739)

Co-Investigator(Renkei-kenkyūsha) SAKUMA Yuko  日本医科大学, 医科研究科, 教授 (70094307)
KIYAMA Yuko  日本医科大学, 医科研究科, 講師 (60234390)
Project Period (FY) 2009 – 2011
Keywordsプロテオーム / エストロゲン / シグナル伝達 / シグナルカスケード / 脳神経系
Research Abstract

In the present study, we found new signaling pathways for estrogenic chemicals and created a new way of evaluation of such chemicals by means of the profiling of the expression of estrogen-responsive genes and a comprehensive analysis of intracellular signal transduction.

  • Research Products

    (30 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (18 results) Book (1 results)

  • [Journal Article] Estrogenic activity of bio-degradation products of C-heavy oil revealed by gene expression profiling using an oligo-DNA microarray system2012

    • Author(s)
      Zhu, Y., Kitamura, K., Maruyama, M., Higashihara, T., Kiyama, R.
    • Journal Title

      Environ. Pollution

      Volume: 168 Pages: 10-14

    • DOI

      DOI:10.1016/j.envpol.2012.04.005

    • Peer Reviewed
  • [Journal Article] Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells.2012

    • Author(s)
      Liao, Y., Wang, J., Huang, Q.-s., Fang, C., Kiyama, R., Shen, H. and Sijun Dong, S.
    • Journal Title

      Environ. Pollution

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract2012

    • Author(s)
      Dong, S., Furutani, Y., Suto, Y., Furutani, M., Zhu, Y., Yoneyama, M., Kato, T., Itabe, H., Nishikawa, T., Tomimatsu, H., Tanaka, T., Kasanuki, H., Masaki, T., Kiyama, R. and Matsuoka, M.
    • Journal Title

      Microbiol. Res

      Volume: 167 Pages: 231-237

    • DOI

      DOI:10.1016/j.micres.2011.09.003

    • Peer Reviewed
  • [Journal Article] Effects of BIG1 and KANK1 on cell polarity and directed migration during wound healing2011

    • Author(s)
      Li, C.-C., Kuo, J.-C., Waterman, C. M., Kiyama, R., Moss, J. and Vaughan, M.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 108 Pages: 19228-19233

    • DOI

      DOI:10.1073/pnas.1117011108

    • Peer Reviewed
  • [Journal Article] A conserved regulatory element in the mammalian beta-globin promoters2011

    • Author(s)
      Kiyama, R. and Wada-Kiyama, Y.
    • Journal Title

      J. Mol. Evol

      Volume: 73 Pages: 101-108

    • DOI

      DOI:10.1007/s00239-011-011-9459-y

    • Peer Reviewed
  • [Journal Article] Application of Fluolid-Orange-labeled probes for DNA microarray and immunological assays2011

    • Author(s)
      Zhu, Y., Ogaeri, O., Suzuki, J.-i., Dong, S., Aoyagi, T., Mizuki, K., Takasugi, M., Isobe, S.-i. and Kiyama, R.
    • Journal Title

      Biotechnol. Letts

      Volume: 33 Pages: 1759-1766

    • DOI

      DOI:10.1007/s10529-011-0646-0

    • Peer Reviewed
  • [Journal Article] Functions of Kank1 and carcinogenesis2011

    • Author(s)
      Kakinuma, N., Zhu, Y., Ogaeri, T., Suzuki J.-i. and Kiyama, R.
    • Journal Title

      Tumor Suppressors(Richard Schortemeyer III, ed.)

      Pages: 161-173

    • URL

      http://www.novapublishers.com

    • Peer Reviewed
  • [Journal Article] A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells2011

    • Author(s)
      Dong, S., Terasaka, S. and Kiyama, R. Bisphenol
    • Journal Title

      Environmental Pollution

      Volume: 159 Pages: 212-218

    • DOI

      DOI:10.1016/j.envpol.2010.09.004

    • Peer Reviewed
  • [Journal Article] Kank proteins : Structure, functions and diseases2009

    • Author(s)
      Kakinuma, N., Zhu, Y., Wang, Y., Roy B. C. and Kiyama R.
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 66 Pages: 2651-2659

    • DOI

      DOI:10.1007/s00018-009-0038-y

    • Peer Reviewed
  • [Journal Article] A major mutation of KIF21A associated with congenital fibrosis of the extraocular muscles type 1(CFEOM1) enhances translocation of Kank1 to the membrane2009

    • Author(s)
      Kakinuma, N. and Kiyama, R.
    • Journal Title

      Biochem. Biophys. Res. Comm

      Volume: 386 Pages: 639-644

    • DOI

      DOI:10.1016/j.bbrc.2009.06.109

    • Peer Reviewed
  • [Journal Article] Expression profiling of the genes responding to zearalenone and its analogues using estrogen-responsive genes2009

    • Author(s)
      Parveen, M., Zhu Y. and Kiyama, R.
    • Journal Title

      FEBS Letters

      Volume: 583 Pages: 2377-2384

    • DOI

      DOI:10.1016/j.febslet.2009.06.035

    • Peer Reviewed
  • [Presentation] Actin dynamics in the sexually dimorphic nucleus of the rat preoptic area during the critical period2012

    • Author(s)
      Y. Wada-Kiyama, C. Suzuki, T. Hamada, R. Kiyama, Y. Sakuma
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-31
  • [Presentation] ジャトロファ精製油および搾りかすの生理活性評価2012

    • Author(s)
      朱耘、木山亮一
    • Organizer
      第11回産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      茨城県産総研共用講堂
    • Year and Date
      2012-01-31
  • [Presentation] 新規蛍光物質Fluolidを用いた多重染色法によるヒト腎臓癌の病理診断法の開発2012

    • Author(s)
      Dilibaier Wuxiuer、魚返拓利、朱耘、鈴木順一朗、青柳貞一郎、礒部信一郎、木山亮一
    • Organizer
      第11回産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      茨城県産総研共用講堂
    • Year and Date
      2012-01-31
  • [Presentation] テーラーメイド医療用診断機器(DNAチップ): DNAチップ<開発ガイドライン>次世代医療機器2012

    • Author(s)
      木山亮一
    • Organizer
      開発ガイドライン・評価指標セミナー
    • Place of Presentation
      東京都日本教育会館
    • Year and Date
      2012-01-20
  • [Presentation] Signaling of estrogen to actin dynamics via cofilin controls sexually dimorophic formation of the rat preoptic area2011

    • Author(s)
      Y. Wada-Kiyama, C. Suzuki, T. Hamada, R. Kiyama, Y. Sakuma
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県パシフィコ横浜
    • Year and Date
      2011-12-16
  • [Presentation] DNAマイクロアレイアッセイを用いた重油微生物分解産物のエストロゲン活性の評価2011

    • Author(s)
      朱耘、北村恵子、丸山明彦、東原孝規、木山亮一
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県パシフィコ横浜
    • Year and Date
      2011-12-16
  • [Presentation] 新規蛍光色素Fluolidを用いた多重染色法によるヒト腎臓癌の病理診断法の開発2011

    • Author(s)
      Dilibaier Wuxiuer、魚返拓利、朱耘、鈴木順一朗、青柳貞一郎、礒部信一郎、木山亮一
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県パシフィコ横浜
    • Year and Date
      2011-12-13
  • [Presentation] オミックス解析による天然・人工化合物のエストロゲン活性評価2011

    • Author(s)
      木山亮一
    • Organizer
      第29回内分泌代謝学サマーセミナー
    • Place of Presentation
      宮城県艮陵会館
    • Year and Date
      2011-07-07
  • [Presentation] オリゴDNAマイクロアレイアッセイによる重油微生物分解産物のエストロゲン活性評価2011

    • Author(s)
      北村恵子、丸山明彦、東原孝規、朱耘、木山亮一
    • Organizer
      第10回産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      茨城県産総研共用講堂
    • Year and Date
      2011-02-01
  • [Presentation] Kank1によるDaam1及びRhoを介する中心体複製と細胞質分裂の制御2011

    • Author(s)
      魚返拓利、鈴木順一朗、Roy BC、垣沼直人、木山亮一
    • Organizer
      第10回産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      茨城県産総研共用講堂
    • Year and Date
      2011-02-01
  • [Presentation] Expression profiling of the estrogen-responsive genes in response to capsaicinoids using an oligo-DNA microarray assay system2011

    • Author(s)
      朱耘、木山亮一
    • Organizer
      第10回産総研・産技連LS-BT合同研究発表会
    • Place of Presentation
      茨城県産総研共用講堂
    • Year and Date
      2011-02-01
  • [Presentation] Effects of BIG1 and KANK1 on Cell Polarity and Directed Migration during Wound Healing2010

    • Author(s)
      C. Li, J. Kuo, R. Kiyama, J. Moss, M. Vaughan
    • Organizer
      50th Annual Meeting of the American Society of Cell Biology
    • Place of Presentation
      Philadelphia Convention Center,(米国ペンシルベニア州)
    • Year and Date
      2010-12-11
  • [Presentation] Intracellular signalling stimulated by synthetic estrogenic chemicals and natural phytoestrogens2010

    • Author(s)
      yoiti Kiyama
    • Organizer
      2nd Xiamen International Forum on Urban and Environment(XIFUE)
    • Place of Presentation
      厦門市(中国)中国科学院都市環境研究所
    • Year and Date
      2010-12-11
  • [Presentation] Kank1によるDaam1及びRhoを介する細胞質分裂の制御2010

    • Author(s)
      鈴木順一朗, Badal. C Roy,垣沼直人,木山亮一
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
  • [Presentation] Evaluation of Estrogenic Activity of Flavonoids by an Oligo-DNA Microarray Assay2010

    • Author(s)
      Yun Zhu, Ryoiti Kiyama
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
  • [Presentation] Estradiol-induced signaling involved in the sexual differentiation of the rat preoptic area2010

    • Author(s)
      Chiaki Suzuki, Tomohiro Hamada, Ryoiti Kiyama, Yasuo Sakuma, Yuko Wada-Kiyama
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
  • [Presentation] Diverse Regulatory Actions of BIG1 and 2 Related to their ARF-activaing and KAP Functions2010

    • Author(s)
      Chun-Chun Li, Xiaoyan Shen, Ermanno Puxeddu, Jean-Cheng Kuo, Ryoiti Kiyama, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan
    • Organizer
      FASEB meeting(Arf Family G Proteins)
    • Place of Presentation
      Carefree ResortホテルCarefree(米国アリゾナ州)
    • Year and Date
      2010-08-15
  • [Presentation] DNA microarray analysis for evaluation of estrogenicity of natural and synthetic compounds2009

    • Author(s)
      木山亮一
    • Organizer
      中国科学院都市環境研究所「環境及び健康研究学術報告会」環境研究所
    • Place of Presentation
      中国厦門
    • Year and Date
      2009-11-26
  • [Book] バイオ知財入門2010

    • Author(s)
      木山亮一, 他
    • Total Pages
      257
    • Publisher
      三和書籍

URL: 

Published: 2013-07-31  

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