2011 Fiscal Year Final Research Report
Development of Natural Product-Derived Innate Immune Regulators Using Insect Immune Systems
| Project/Area Number |
21310134
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Haruhisa 東北大学, 大学院・薬学研究科, 准教授 (90302166)
KATOU Yasuhiro 東北大学, 大学院・薬学研究科, 助教 (50455797)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 微生物 / 自然免疫 / 天然物 |
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| Research Abstract |
A new trichostatin analog and a new aurelic acid analog were isolated from Streptomyces hygroscopicus and Streptomyces sp. as an innate immune inhibitor inhibitory and a transcription/translation inhibitory compound, respectively. In addition, a stereostructure of gonytolide A, an innate immune activator, was determined, and its analogs were isolated from Gonytrichum sp. Structure-activity relationship study based on celastramycin A and gonytolide A was also carried out.
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