Synthesis of α-Amino Squaric Acid Incorporated Peptides and Their Biological Activities

2012 Fiscal Year Final Research Report

• Project/Area Number: 21310145
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Osaka City University
• Principal Investigator: SHINADA Tetsuro 大阪市立大学, 大学院・理学研究科, 教授 (30271513)
• Project Period (FY): 2009 – 2012
• Keywords: ペプチド / スクアリン酸 / 固相合成 / ペプチドアナログ

Research Abstract

Peptides are one of the pivotal biological materials that plays an important role in biological function. Due to their crucial roles, development of peptide analogs as a tool for investigation of peptide function has attracted much attention from the rese

Research Products

• [Journal Article] Stereoselective Synthesis of E-α,β-Dehydroamino Acid Esters (2013)
  • Author(s): Y. Yasuno, M. Hamada, T. Yamada, T. Shinada,Y. Ohfune
  • Journal Title: Eur. J. Org. Chem. Pages: 1884-1888
  • Peer Reviewed
• [Journal Article] Mild and Catalytic Transesterification Reaction using K_2HPO_4 for the Synthesis of Methyl Esters (2010)
  • Author(s): T. Shinada, M. Hamada, K. Miyoshi, M. Higashino, T. Umezawa, Y. Ohfune
  • Journal Title: Synlett Pages: 2141-2145
  • Peer Reviewed
• [Journal Article] Thiol addition to t-butyl methyl squarate. efficient synthesis of novel sulfur-linked squaryl group-containing glutamate analogs. (2009)
  • Author(s): T. Shinada, A. Yamasaki, Y. Kiniwa, K. Shimamoto, Y. Ohfune
  • Journal Title: Tetrahedron Lett Pages: 4354-4357
  • Peer Reviewed
• [Journal Article] Asymmetric Synthesis of α,α-disubstituted α-amino acids: Strecker and Claisen Approaches. (2009)
  • Author(s): Y. Ohfune, K. Sakaguchi, T. Shinada
  • Journal Title: ACS Symposium Series Volume: 1009 Pages: 57-71
  • Peer Reviewed
• [Presentation] 固相合成による α-アミノスクアリン酸含有ペプチドの合成 (2013)
  • Author(s): 前田健太郎、品田哲郎、大船泰史
  • Organizer: 日本化学会第93 春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
  • Year and Date: 20130322-25
• [Presentation] Synthesis of Novel Peptide Analog by Iterative Linkage of Squaric Acid-Containing Amino Acid (2012)
  • Author(s): K. Maeda, T. Shinada, Y. Ohfune
  • Organizer: The Twelfth International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-12)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20121212-16
• [Presentation] スクアリン酸含有アミノ酸を組み込んだ新規ペプチドアナログ合成 (2012)
  • Author(s): 前田健太郎、木庭雄一、石田捻和、品田哲郎、大船泰史
  • Organizer: 第54回天然有機化合物討論会
  • Year and Date: 20120918-20
• [Presentation] 非天然型アミノ酸構造を有する天然有機化合物の全合成研究 (2012)
  • Author(s): 品田哲郎
  • Organizer: 第39回有機反応懇談会
  • Place of Presentation: 関西大学千里山キャンパス
  • Year and Date: 2012-08-03
• [Presentation] Synthesis of Squaric Acid-containing Amino Acid and Its Incorporation into Peptide (2011)
  • Author(s): T. Shinada, Y. Kiniwa, Y. Ohfune
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Keio Plaza Hotel, Japan
  • Year and Date: 20111129-1202
• [Presentation] α-アミノスクアリン酸含有ペプチドライブラリーの合成研究 (2011)
  • Author(s): 木庭雄一、品田哲郎、大船泰史
  • Organizer: 日本化学会第91 春季年会
  • Place of Presentation: 神奈川大学横浜キャンパス
  • Year and Date: 20110326-29
• [Presentation] Incorporation of Squaric Acid-containing Amino Acid into Peptide (2010)
  • Author(s): T. Shinada, Y. Kiniwa, T. Ishida, and Y. Ohfune
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem)
  • Place of Presentation: Hawaii, USA
  • Year and Date: 20101210-15
• [Presentation] Synthesis of α-Amino Squaric Acid and Its Incorporation into Peptide (2009)
  • Author(s): T. Shinada, T. Ishida, A. Yamasaki, Y. Kiniwa, Y. Ohfune
  • Organizer: Tenth Tetrahedron Symposium
  • Place of Presentation: Paris, France
  • Year and Date: 20090624-26
• [Presentation] 精密有機合成を駆使した微量生理活性分子の構造決定 (2009)
  • Author(s): 品田哲郎
  • Organizer: 第36回有機反応懇談会
  • Place of Presentation: 関西学院大学
  • Year and Date: 2009-08-03
• [Remarks]
  • URL: http://www.sci.osaka-cu.ac.jp/chem/henkan/index.html