2012 Fiscal Year Final Research Report
Spiral Formation of Exc itation Waves Based on Curvature Effect in Culture of Cardiomyocyt
| Project/Area Number |
21340120
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Kyoto University |
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Principal Investigator |
アグラゼ コンスタンチン 京都大学, 物質-細胞統合システム拠点, 教授 (30503651)
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| Co-Investigator(Kenkyū-buntansha) |
MAGOME Nobuyuki 京都大学, 物質-細胞統合システム拠点, 助教 (70390052)
MOTOIKE Ikuko 京都大学, 物質-細胞統合システム拠点, 研究員 (70347178)
IMAMURA Hisako 京都大学, 物質-細胞統合システム拠点, 研究員 (30523790)
ORLOVA Yuliya 京都大学, 物質-細胞統合システム拠点, 研究員 (90571901)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 非線形振動 / 興奮性 / 曲率効果 / 心筋細胞 / ラセン波 / 反応拡散方程式 / パターン形成 / 光制御 |
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| Research Abstract |
Behaviors of traveling excitation waves around obstacle region in cultivated cardiomyocytes were investigated in experimentally and numerically. The instability of propagation waves were affected by excitability of the cells and shape of obstacle.Spontaneous formation of spiral wave at edge of sharp corner was also observed.Furthermore, new methods (1) to control activity of cardiomyocytes with the aid of photo-switching molecules, and (2) to construct aligned culture of cells along fabricated microfiber were established
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