2011 Fiscal Year Final Research Report
Chiral Memory Using the Property of Organic Crystals
| Project/Area Number |
21350024
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
SAKAMOTO Masami 千葉大学, 大学院・工学研究科, 教授 (00178576)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 有機光化学 / 有機合成化学 / 不斉合成 / 有機結晶 |
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| Research Abstract |
New absolute asymmetric synthesis using the property of organic crystals were developed. Crystallization under various conditions was examined and was clarified a change of molecular structure, polymorphism and the crystal structure. Furthermore, I succeeded in controlling the rate of racemization of the apparent chiral molecules in the chiral crystals, and leading it effectively to the optically active products. I also developed the highly diastereoselective reaction using chiral memory controlled by crystallization induced diastereomer transformation (CIDT).
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