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2011 Fiscal Year Final Research Report

Highly Stereocontrolled Construction of Acyclic Systems Utilizing Titanocene Complexes as Synthetic Devices

Research Project

  • PDF
Project/Area Number 21350026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Organic chemistry
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

TAKEDA Takeshi  東京農工大学, 大学院・工学研究院, 教授 (40111455)

Project Period (FY) 2009 – 2011
Keywords合成有機化学
Research Abstract

New processes for the stereocontrolled construction of acyclic systems bearing consecutive stereogenic centers and highly conjugated systems utilizing various titanocene complexes such as allyltitanocenes, alkylidenetitanocenes, and titanacycles as synthetic devices.

  • Research Products

    (19 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Highly Diastereoselective Addition of Allyltitanocenes toα-Chiral Ketones2012

    • Author(s)
      T. Takeda, S. Yoshida, T. Nishimura, A. Tsubouchi
    • Journal Title

      Tetrahedron Lett

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Highly Diastereoselective Construction of Acyclic Systems with Two Consecutive Quaternary Stereocenters by Allylation of Ketones2012

    • Author(s)
      T. Takeda, M. Yamamoto, S. Yoshida, A. Tsubouchi
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Diastereoselective Addition of Allyltitanocenes to Cyclic Enones2012

    • Author(s)
      T. Takeda, T. Nishimura, S. Yoshida, F. Saiki, Y. Tajima, A. Tsubouchi
    • Journal Title

      Org. Lett

      Volume: 14 Pages: 2042-2045

    • DOI

      DOI:10.1021/ol300562g

    • Peer Reviewed
  • [Journal Article] Regio-and Stereoselective Synthesis of 1, 4-Dienes2011

    • Author(s)
      S. Oishi, K. Hatano, A. Tsubouchi, T. Takeda
    • Journal Title

      Chem. Commun

      Volume: 47 Pages: 11639-11640

    • DOI

      DOI:10.1039/c1cc14765j

    • Peer Reviewed
  • [Journal Article] Regio-and Stereoselective Preparation of Highly Substi-tuted Tertiary Homoallylic Alcohols2011

    • Author(s)
      T. Takeda, H. Wasa, A. Tsubouchi
    • Journal Title

      Tetrahedron Lett

      Volume: 52 Pages: 4575-4578

    • Peer Reviewed
  • [Journal Article] Highly Stereoselective Construction of Multiple Stereogenic Centers Using Allylic Sulfides2011

    • Author(s)
      T. Takeda, Y. Yatsumonji, T. Nishimura, T. Sugita, A. Tsubouchi
    • Journal Title

      Phosphorus, Sulfur and Silicon and the Related Elements

      Volume: 186 Pages: 1229-1233

    • DOI

      DOI:10.1080/10426507.2010.507727

  • [Journal Article] Stereo-selective Formation of Phenylthio Groups Substituted 1-Metalla-3-titanacyclobutanes2011

    • Author(s)
      S. Oishi, A. Tsubouchi, T. Takeda
    • Journal Title

      J. Organomet. Chem

      Volume: 696 Pages: 581-585

    • DOI

      DOI:10.1016/j.jorganchem.2010.09.080

    • Peer Reviewed
  • [Journal Article] [2+2+1] Cycloaddition between Alkynes, Acry-lates, and Titanocene(II): Regioselective For-mation of 5-Alkoxycarbonyltitanacyclopent-2-enes and Their Addition to Carbonyls2010

    • Author(s)
      S. Oishi, K. Ohomika, A. Tsubouchi, T. Takeda
    • Journal Title

      Chem. Lett

      Volume: 39 Pages: 723-725

    • DOI

      DOI:10.1246/cl.2010.723

    • Peer Reviewed
  • [Journal Article] Preparation of syn-Tertiary Homoallylic Alcohols Utilizing Allenyltitanocenes Generated by Reductive Titanation ofγ-Trimethylsilyl-propargylic Carbonates2010

    • Author(s)
      Y. Yatsumonji, T. Sugita, A. Tsubouchi, T. Takeda
    • Journal Title

      Org. Lett

      Volume: 12 Pages: 1968-1971

    • DOI

      DOI:10.1021/ol100395n

    • Peer Reviewed
  • [Journal Article] Highly Stereoselective Preparation of Tertiary Homoallylic Alcohols Having Multi-Stereogenic Centers2010

    • Author(s)
      T. Takeda, T. Nishimura, Y. Yatsumonji, K. Noguchi, A. Tsubouchi
    • Journal Title

      Chem. Eur. J

      Volume: 16 Pages: 4729-4732

    • DOI

      DOI:10.1002/chem.201000101

    • Peer Reviewed
  • [Journal Article] Regio-and Stereoselective Formation of Conjugated Dienes by Titanocene(II)-Promoted Alkylation of Propargyl Carbonates2009

    • Author(s)
      Y. Yatsumonji, Y. Atake, A. Tsubouchi, T. Takeda
    • Journal Title

      Chem. Commun

      Pages: 3375-3377

    • DOI

      DOI:10.1039/b905782j

    • Peer Reviewed
  • [Journal Article] Highly Diastereoselective Addition of Allyltitanocenes to Ketones2009

    • Author(s)
      Y. Yatsumonji, T. Nishimura, A. Tsubouchi, K. Noguchi, T. Takeda
    • Journal Title

      Chem. Eur. J

      Volume: 15 Pages: 2680-2686

    • DOI

      DOI:10.1002/chem.200802340

    • Peer Reviewed
  • [Presentation] Highly stereoselective construction of multiple stereogenic centers by the reactions of allyl-and allenyltitanocenes with ketones2010

    • Author(s)
      Takeshi Takeda
    • Organizer
      2010 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-15
  • [Presentation] Organosulfur Compounds in Acyclic Stereoselection2010

    • Author(s)
      Takeshi Takeda
    • Organizer
      XII National Symposium "Advances in the Chemistry of Heteroorganic Compounds"
    • Place of Presentation
      Lodz, Poland
    • Year and Date
      2010-11-19
  • [Presentation] Organosulfur Compounds in Acyclic Stereoselection2010

    • Author(s)
      Takeshi Takeda
    • Organizer
      Xth International Symposium on Selected Problems of Chemistry of Acyclic and Cyclic Heteroorganic Compounds
    • Place of Presentation
      Czestochowa, Poland
    • Year and Date
      2010-11-18
  • [Presentation] Highly Stereoselective Construction of Multiple Stereogenic Centers Using Allylic Sulfides2010

    • Author(s)
      Takeshi Takeda
    • Organizer
      24th International Symposium on the Organic Chemistry of Sulfur
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2010-07-27
  • [Presentation] Construction of arrays of stereogenic centers by the reactions of allyl-and allenyltitanocenes with ketones2010

    • Author(s)
      Takeshi Takeda
    • Organizer
      The 6th Asian-European Symposium on Metal-Mediated Reactions
    • Place of Presentation
      Singapore
    • Year and Date
      2010-06-08
  • [Presentation] Organic Synthesis via Formation of Titanacyclobutenes2009

    • Author(s)
      Takeshi Takeda
    • Organizer
      15^<th> IUPAC International Symposium on Organometallic Chemistry Directed Toward Organic Synthesis
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2009-07-27
  • [Book] Organometallic complexes of titanium(update 2011)2011

    • Author(s)
      T. Takeda, A. Tsubouchi, Georg Thieme Verlag
    • Total Pages
      1-36
    • Publisher
      Science of Synthesis

URL: 

Published: 2013-07-31  

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