Development of New Strategy for Analysis of Chromatographic Behavior on the Basis of Moment Theory

2011 Fiscal Year Final Research Report

• Project/Area Number: 21350040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: University of Toyama
• Principal Investigator: MIYABE Kanji 富山大学, 大学院・理工学研究部, 教授 (10281015)
• Project Period (FY): 2009 – 2011
• Keywords: クロマトグラフィー / 分離化学 / モーメント理論

Research Abstract

Now, various separation media having different structural characteristics of shapes and porosities, such as silica monoliths and core-shell spherical particles, are developed for improving the separation speed and efficiency of high performance liquid chromatography, which has widely been used as one of the most powerful methods for fine separation and chemical analysis. In this study, a new strateg(theory, experimental method, and data analysis procedure) was developed for quantitatively analyzing the separation properties and mechanisms of the different packing materials in detail. The strategy can provide new information about chromatographic behavior, which cannot be derived by conventional theories and models, such as the rate theory of chromatography.

Research Products

• [Journal Article] Moment Analysis of Chromatographic Behavior of Superficially Porous Particles (2011)
  • Author(s): Miyabe, K.; Noiri, K.; Kobayashi, K
  • Journal Title: Anal. Sci Volume: 27 Pages: 1097-1105
  • Peer Reviewed
• [Journal Article] Moment Equations for Chromatography Using Superficially Porous Spherical Particles (2011)
  • Author(s): Miyabe, K
  • Journal Title: Anal. Sci Volume: 27 Pages: 1007-1017
  • Peer Reviewed
• [Journal Article] Estimation of Molecular Diffusivity in Aqueous Solution of Acetonitrile by the Wilke-Chang Equation (2011)
  • Author(s): Miyabe, K
  • Journal Title: J. Sep. Sci Volume: 34 Pages: 2674-2679
  • Peer Reviewed
• [Journal Article] Isogai, R., Estimation of Molecular Diffusivity in Liquid Phase Systems by the Wilke-Chang Equation (2011)
  • Author(s): Miyabe, K
  • Journal Title: J. Chromatogr. A Volume: 1218 Pages: 6639-6645
  • Peer Reviewed
• [Journal Article] Extrathermodynamic Study of Retention Equilibrium in RP-LC Using a C_18-Silica Monolithic Stationary Phase (2011)
  • Author(s): Miyabe, K.; Matsushima, A
  • Journal Title: Chromatographia Volume: 74 Pages: 179-187
  • Peer Reviewed
• [Journal Article] Monolithic Silica Rod Columns for High-Efficiency Reversed-Phase Liquid Chromatography (2011)
  • Author(s): Miyazaki, S.; Takahashi, M.; Ohira, M.; Terashima, H.; Morisato, K.; Nakanishi, K.; Ikegami, T.; Miyabe, K.; Tanaka, N
  • Journal Title: J. Chromatogr. A Volume: 1218 Pages: 1988-1994
  • Peer Reviewed
• [Journal Article] Numerical Method for the Estimation of Column Radial Heterogeneity and of the Actual Column Efficiency from Tailing Peak Profiles (2011)
  • Author(s): Miyabe, K.; Guiochon, G
  • Journal Title: Anal. Chem Volume: 83 Pages: 182-192
  • Peer Reviewed
• [Journal Article] External Mass Transfer in Silica Monolithic Stationary Phases (2010)
  • Author(s): Miyabe, K.; Ando, N.; Nakamura, T.; Guiochon, G
  • Journal Title: Chem. Eng. Sci Volume: 65 Pages: 5950-5960
  • Peer Reviewed
• [Journal Article] Peak Parking-Moment Analysis : A Strategy for the Measurement of Molecular Diffusivity in Liquid Phase (2010)
  • Author(s): Miyabe, K.; Nagai, J.-i.; Guiochon, G
  • Journal Title: Chem. Eng. Sci Volume: 65 Pages: 3859-3864
  • Peer Reviewed
• [Journal Article] Kinetic Study on External Mass Transfer in High Performance Liquid Chromatography System (2010)
  • Author(s): Miyabe, K.; Kawaguchi, Y.; Guiochon, G
  • Journal Title: J. Chromatogr. A Volume: 1217 Pages: 3053-3062
  • Peer Reviewed
• [Journal Article] An Estimation of the Column Efficiency Made by Analyzing Tailing Peak Profile (2009)
  • Author(s): Miyabe, K.; Matsumoto, Y.; Niwa, Y.; Ando, N.; Guiochon, G
  • Journal Title: J. Chromatogr. A Volume: 1216 Pages: 8319-8330
  • Peer Reviewed
• [Journal Article] Surface Diffusion in C_18-Silica Monolithic Stationary Phase (2009)
  • Author(s): Miyabe, K
  • Journal Title: J. Chromatogr. Sci Volume: 47 Pages: 452-458
  • Peer Reviewed
• [Journal Article] Peak Parking Method for Measurement of Molecular Diffusivity in Liquid Phase Systems (2009)
  • Author(s): Miyabe, K.; Ando, N.; Guiochon, G
  • Journal Title: J. Chromatogr. A Volume: 1216 Pages: 4377-4382
  • Peer Reviewed
• [Journal Article] Thermodynamic Interpretation of Retention Equilibrium in Reversed-Phase Liquid Chromatography (2009)
  • Author(s): Miyabe, K
  • Journal Title: Anal. Sci Volume: 25 Pages: 219-227
  • Peer Reviewed
• [Journal Article] Peak Parking-Moment Analysis Method for the Measurement of Surface Diffusion Coefficient (2009)
  • Author(s): Miyabe, K.; Matsumoto, Y.; Ando, N
  • Journal Title: Anal. Sci Volume: 25 Pages: 211-218
  • Peer Reviewed
• [Presentation] テーリングピーク形状から物質移動速度を正確にモーメント解析する方法 (2011)
  • Author(s): 宮部寛志, G. Guiochon
  • Organizer: 第22回クロマトグラフィー科学会議
  • Place of Presentation: 仙台
  • Year and Date: 2011-10-21
• [Presentation] モーメント理論に基づく高性能高速液体クロマトグラフィー用分離剤の分離挙動の解析 (2011)
  • Author(s): 宮部寛志
  • Organizer: 日本分析化学会第60年会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-09-15
• [Presentation] Moment Equations for Chromatography Using Superficially Porous Spherical Particles (2011)
  • Author(s): Miyabe, K
  • Organizer: 36th International Symposium on High Performance Liquid Phase Separations and Related Techniques(HPLC 2011)
  • Place of Presentation: Budapest
  • Year and Date: 2011-06-22
• [Presentation] シェル型粒子を用いるクロマトグラフィーに対する新規モーメント解析式の開発 (2011)
  • Author(s): 宮部寛志
  • Organizer: 第18回クロマトグラフィーシンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-03
• [Presentation] Measurement of Molecular Diffusivity in Liquid Phase Systems (2011)
  • Author(s): Miyabe, K
  • Organizer: International Congress on Analytical Sciences 2011(ICAS2011)
  • Place of Presentation: Kyoto
  • Year and Date: 2011-05-25
• [Presentation] Molecular Migration on Stationary Phase Surface in Reversed-Phase Liquid Chromatography【依頼講演】 (2010)
  • Author(s): Miyabe, K
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies(Pacifichem 2010)
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-15
• [Presentation] クロマトグラフィー系におけるテーリングピークの数値解析法 (2010)
  • Author(s): 宮部寛志, G. Guiochon
  • Organizer: 第21回クロマトグラフィー科学会議
  • Place of Presentation: 西宮
  • Year and Date: 2010-10-22
• [Presentation] Kinetic Study on External Mass Transfer in RPLC System (2010)
  • Author(s): Miyabe, K.; Guiochon, G
  • Organizer: 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques(HPLC 2010)
  • Place of Presentation: Boston
  • Year and Date: 2010-06-21
• [Presentation] Monolithic Silica Columns for High-Speed and High-Efficiency HPLC Separations (2010)
  • Author(s): Tanaka, N.; Miyazaki, S.; Takahashi, M.; Ohira, M.; Terashima, H.; Morisato, K.; Nakanishi, K.; Miwa, S.; Ikegami, T.; Hosoya, K.; Miyabe, K
  • Organizer: 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques(HPLC 2010)
  • Place of Presentation: Boston
  • Year and Date: 2010-06-21
• [Presentation] 逆相液体クロマトグラフィー系における液境膜物質移動係数の測定 (2010)
  • Author(s): 宮部寛志,安藤元喜,安藤伸歩
  • Organizer: 第17回クロマトグラフィーシンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2010-06-04
• [Presentation] Surface Diffusion in Reversed-Phase Liquid Chromatography (2010)
  • Author(s): Miyabe, K.; Guiochon, G
  • Organizer: 10th International Conference on Fundamentals of Adsorption(FOA10)
  • Place of Presentation: Awaji
  • Year and Date: 2010-05-24
• [Presentation] Peak Parking Method for Measurement of Molecular Diffusivity in Liquid Phase Systems (2010)
  • Author(s): Miyabe, K
  • Organizer: 23rd International Symposium, Exhibit & Workshops on Preparative/Process Chromatography(PREP 2010)
  • Place of Presentation: Philadelphia
  • Year and Date: 2010-05-12
• [Presentation] モーメント理論に基づくクロマトグラフィー挙動解析法の開発【招待講演,平成21年度クロマトグラフィー科学会学会賞受賞】 (2009)
  • Author(s): 宮部寛志
  • Organizer: 第20回クロマトグラフィー科学会議
  • Place of Presentation: 東京
  • Year and Date: 2009-11-12
• [Presentation] テーリングピーク形状の数値解析によるカラム性能評価 (2009)
  • Author(s): 宮部寛志, G. Guiochon
  • Organizer: 第20回クロマトグラフィー科学会議
  • Place of Presentation: 東京
  • Year and Date: 2009-11-11
• [Presentation] クロマトグラフィー系における非対称性ピーク形状の数値解析法 (2009)
  • Author(s): 宮部寛志
  • Organizer: 日本分析化学会第58年会
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-24
• [Presentation] Estimation of Column Efficiency by Analyzing Tailing Peak Profiles (2009)
  • Author(s): Miyabe, K
  • Organizer: 22nd International Symposium, Exhibit & Workshops on Preparative/Process Chromatography(PREP 2009)
  • Place of Presentation: Philadelphia
  • Year and Date: 2009-07-20
• [Presentation] A Numerical Method for Analysis of Tailing Peak Profiles (2009)
  • Author(s): Miyabe, K.; Guiochon, G
  • Organizer: 34th International Symposium on High Performance Liquid Phase Separation and Related Techniques(HPLC 2009)
  • Place of Presentation: Dresden
  • Year and Date: 2009-06-29
• [Presentation] ピークパーキング法による液相系分子拡散係数の測定 (2009)
  • Author(s): 宮部寛志,安藤伸歩, G. Guiochon
  • Organizer: 第16回クロマトグラフィーシンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 2009-05-29
• [Book] 分析化学用語辞典 (2011)
  • Author(s): 宮部寛志
  • Publisher: オーム社(東京)
• [Remarks] 総説Miyabe, K.; Guiochon, G., Surface Diffusion in Reversed-Phase Liquid Chromatography, J. Chromatogr. A(査読有) 2010, 1217, 1713-1734総説
• [Remarks] Miyabe, K., Development of New Strategy for Analysis of Chromatographic Behavior on the Basis of Moment Theory, CHROMATOGRAPHY(査読有) 2010, 31, 1-15総説
• [Remarks] Miyabe, K., Moment Analysis of Chromatographic Behavior in Reversed-Phase Liquid Chromatography, J. Sep. Sci.(査読有) 2009, 32, 757-770総説
• [Remarks] 宮部寛志,外表面多孔性球状粒子分離剤を用いる高性能高速液体クロマトグラフィー,ぶんせき(日本分析化学会) 2009, No.1, 30-31解説
• [Remarks] 宮部寛志,クロマトグラフィー技術開発の二面性, LC talk(株式会社島津製作所) 2009, 72, 2解説