2011 Fiscal Year Final Research Report
Metallomics of cells and organisms at different stages of development
| Project/Area Number |
21350041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
UMEMURA Tomonari 名古屋大学, エコトピア科学研究所, 准教授 (10312901)
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Kazumi 独立行政法人産業技術総合研究所, 計測標準研究部門 (50356490)
SYU Yanbei 独立行政法人産業技術総合研究所, 計測標準研究部門 (90422790)
BAN Masatoshi 独立行政法人水産総合研究センター, さけますセンター (80425462)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メタロミクス / オミックス / 1細胞分解 / 受精卵 / 必須微量元素 / 金属タンパク質 / 高速分離 / モノリス |
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| Research Abstract |
In the" omics" era, there is a great need for comprehensive genome-wide multi-element analysis of a single cell and organism, because the combination of different metals and metalloids may exhibit an additive, synergistic, or antagonistic effect on cellular functions. Thus, we have had an intense interest in determining what kind of and how many elements are involved in cells, organs and organisms. In this paper, we have carried out multielement analysis of single celled bacteria(Escherichia coli) and organism(euglena) as well as embryos of chum salmon at different stages of development. The experimental results revealed that trace elements were to some extent selectively transferred from the culture media(or yolk sac) to the cell(or embryonic body) at an appropriate timing.
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[Journal Article] Estimation of the Distribution of Intravenously Injected Adipose Tissue-Derived Stem Cells Labeled with Quantum Dots in Mice Organs through the Determination of their Metallic Components by ICP-MS2011
Author(s)
Y. Takasaki, M. Watanabe, H. Yukawa, A. Sabarudin, K. Inagaki, N. Kaji, Y. Okamoto, M. Tokeshi, Y. Miyamoto, H. Noguchi, T. Umemura, S. Hayashi, Y. Baba, H. Haraguchi
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Journal Title
Anal. Chem
Volume: 83
Pages: 8252-8258
Peer Reviewed
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