2011 Fiscal Year Final Research Report
Asymmetric Reactions Catalyzed by Metal Complexes with two Chiral Ligands
| Project/Area Number |
21350048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHKUMA Takeshi 北海道大学, 大学院・工学研究院, 教授 (50201968)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 触媒的不斉合成 / 不斉シアノシリル化反応 / 不斉水素化反応 / 金属錯体触媒 / アルデヒド / シアノヒドリン / ケトン / アルコール |
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| Research Abstract |
Chiral Ru(II) and Ir(III) complexes developped by our research groupi efficiently catalyzed 1) asymmetric cyanosilylation of aldehydes and ketones, 2) asymmetric hydrogenation of ketones, and 3) asymmetric 1,3-hydride migration of allylic alcohols : 1) Enantioselectivity as high as 99% in the reaction with a substrate-to-catalyst molar ratio (S/C) of 10,000 was achieved. 2) A series of chiral alcohols which is hardly prepared by the other methods was readily synthesized in high enantioselectivity. One of these ractions has been commercialized in the synthetic process of a chiral medicine. 3) The highest enantioselectivity of 98% in the reaction with an S/C of 1000 was achieved
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