2011 Fiscal Year Final Research Report
Development of the Functional Molecules for Genome Targeting Chemistry
| Project/Area Number |
21350086
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGATSUGI Fumi 東北大学, 多元物質科学研究所, 教授 (90208025)
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| Co-Investigator(Kenkyū-buntansha) |
HAGIHARA Shinnya 東北大学, 多元物質科学研究所, 助教 (80373348)
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| Co-Investigator(Renkei-kenkyūsha) |
IMOTO Syuhei 東北大学, 多元物質科学研究所, 助教 (20447189)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核酸・蛋白質・糖化学 / クロスリンク反応 |
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| Research Abstract |
After the human genome project, it is revealed that most of genome has functions without translation to protein. Especially, RNA has a variety of the functions to control the gene expression, for example, rebozyme, riboswich, siRNA and miRNA, so on. In this study, we have developed the novel molecules to recognize strictly the target RNA for regulation of these functions.
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Research Products
(52 results)
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[Journal Article] Production of truncated protein by the crosslink formation of mRNA with 2'-OMe oligoribonucleotide containing 2-amino-6-vinylpurine
Author(s)
Hagihara, S., Kusano, S., Lin, W. C., Chao, X. G., Hori, T., Imoto, S., Nagatsugi, F.
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: (in press)
Peer Reviewed
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