2011 Fiscal Year Final Research Report
Stereocontrolled synthesis of P-modified RNA nucleic acid drugs
| Project/Area Number |
21350088
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | The University of Tokyo |
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Principal Investigator |
WADA Takeshi 東京大学, 大学院・新領域創成科学研究科, 准教授 (90240548)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核酸医薬 / リン原子修飾核酸 / 不斉合成 / siRNA |
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| Research Abstract |
In recent years, a great deal of attention has been focused on siRNA and microRNA as drugs for selective inhibition of gene expression. Toward the practical use of these RNA molecules as therapeutic agents, stabilization of those in vivo is required. In this study, a new method for the stereocontrolled synthesis of phosphorous-modified RNA analogs, which are stable in vivo and expected to be highly effective as drugs, has been developed.
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