2011 Fiscal Year Final Research Report
Determining the regulons and their functions in hyperthermophiles
| Project/Area Number |
21350092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
ATOMI Haruyuki 京都大学, 大学院・工学研究科, 教授 (90243047)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 転写制御因子 / 遺伝子破壊 / regulon / 超好熱菌 / 始原菌 / ゲノム |
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| Research Abstract |
We have previously determined the complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakarensis, and have also established a gene disruption and transcriptome analysis system for this organism. Using this information/technology, we disrupted genes predicted to encode transcription regulation factors. This project has led to the elucidation of multiple regulons, and we have been able to propose the functions of genes in several regulons.
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[Journal Article] Identification of the Phr-dependent heat shock regulon in the hyperthermophilic arch eon, Thermococcus kodakaraensis2010
Author(s)
Kanai, T., Takedomi, S., Fujiwara, S., Atomi, H., Imanaka, T.
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Journal Title
Journal of Biochemistry
Volume: 147(3)
Pages: 361-370
Peer Reviewed
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