2011 Fiscal Year Final Research Report
Devel opment of Neuron Gircuit Fabrication Method with X-Ray Microbeam
| Project/Area Number |
21360041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied physics, general
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| Research Institution | Osaka University |
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Principal Investigator |
IIDA Toshiyuki 大阪大学, 大学院・工学研究科, 教授 (60115988)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Yushi 大阪大学, 大学院・工学研究科, 准教授 (40224547)
SATO Fuminobu 大阪大学, 大学院・工学研究科, 助教 (40332746)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 放射線 / マイクロビーム / 神経細胞 |
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| Research Abstract |
Differentiation of PC12 cell can be individually induced with X-ray microbeam. Neurite extension for the PC12 cell differentiated by radiation was small, compared to normal extension by nerve growth factor(NGF). The maximum differentiation was 14% at absorbed dose 15 Gy. A cell chip to arrange individual cell positions was fabricated with lithography and cell technology. PC12 cells were successfully incubated in the cell chip.
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