2011 Fiscal Year Final Research Report
Development of high-resolution 2D-3D hybrid acoustic impedance microscope for biological use
| Project/Area Number |
21360200
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Measurement engineering
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| Research Institution | Toyohashi University of Technology (2011)
Aichi Institute of Technology (2009-2010) |
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Principal Investigator |
HOZUMI Naohiro 豊橋技術科学大学, 工学教育国際協力研究センター, 教授 (30314090)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Sachiko 豊橋技術科学大学, 大学院・工学研究科, 講師 (40222393)
YAMAMOTO Seiji 浜松医科大学, 光量子医学研究センター, 准教授 (60144094)
SAIJO Yoshifumi 東北大学, 医工学研究科, 教授 (00292277)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Kazuto 本多電子株式会社, メディカル事業部長
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| Project Period (FY) |
2009 – 2011
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| Keywords | 超音波 / 生体組織 / 音響インピーダンス |
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| Research Abstract |
We proposed a new ultrasonic microscope for medical and biological use. The target is placed on a plastic substrate, and ultrasonic signal is transmitted and received across the substrate. In this phase of research, we improved spatial resolution, and observed brain tumor model and cultured glioma cells. As for brain tumor tissue, we succeeded in highlighting the tumor by quantifying" local roughness of acoustic impedance". As for cell size observation, we succeeded in observing morphological change of glioma cells after being exposed to anticancer agent. Finally, we succeeded in three dimensional observation of tumor and cultured cells simultaneously with the observation of cross sectional acoustic impedance image.
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