2011 Fiscal Year Final Research Report
Design of Molecular Assembly for Extraction of Biomolecules
| Project/Area Number |
21360383
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Kyushu University |
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Principal Investigator |
GOTO Masahiro 九州大学, 工学研究院, 教授 (10211921)
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| Co-Investigator(Kenkyū-buntansha) |
NORIHO Kamiya 九州大学, 工学研究院, 教授 (50302766)
FUKIKO Kubota 九州大学, 工学研究院, 助教 (60294899)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 逆ミセル / 溶媒抽出 / マイクロエマルション / 分子集合体 / タンパク質 / DNA |
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| Research Abstract |
Liquid/liquid extraction is one of the useful separation techniques involving a molecular recognition event. Despite a number of studies on liquid/liquid extraction, it is still a challenge to extract a target biomolecule selectively to another phase based on the precise recognition at a liquid/liquid interface. In particular, if the target is a biomacromolecule, the presence of multifunctional groups prevents selectivity and versatility in liquid/liquid extraction. We here propose the sequence-specific liquid/liquid extraction of DNA oligonucleotides using reverse micelles with a DNA-surfactant. A reverse micelle, which is a nanoscale water pool surrounded by surfactant molecules in an organic solvent, is one of the highly useful tools for extraction of biomolecules.
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