2011 Fiscal Year Final Research Report
Structural and Functional Analyses of Intrinsically Unfolded Proteins for Engineering
| Project/Area Number |
21360398
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 蛋白質 / 分子認識 / 生物・生体工学 / ナノバイオ / 天然変性 |
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| Research Abstract |
Functional and physicochemical properties of intrinsically unfolded proteins have been focused. The novel interaction and self-assembly mechanisms have successfully described, based on several physicochemical, structural, and functional analyses. A novel system for handling proteins has been constructed, based on the chemical chaperone-like mechanism of an amino acid and derivatives. For a functionally unknown protein, we elucidated the function from cell-based analyses. A novel target has been used for construction of artificial regulation system of self-assembly process in vitro, showing the potential of proteins used as a tool of a bottom-up process in nano-biotechnology.
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Research Products
(41 results)
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[Journal Article] Interleukin-11 links oxidative stress and compensatory proliferation2012
Author(s)
Nishina T, Komazawa-Sakon S, Yanaka S, Piao X, Zheng DM, Piao JH, Kojima Y, Yamashina S, Sano E, Putoczki T, Doi T, Ueno T, Ezaki J, Ushio H, Ernst M, Tsumoto K, Okumura K, Nakano H
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Journal Title
Sci Signal
Volume: 5
Pages: ra5
DOI
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[Presentation] Aromatic Interactions are Essential for Carbohydrate Recognition by an Enzyme2010
Author(s)
Caaveiro, J. M. M., Kobe, A., Clifton, J. G., Ringe, D., Petsko, G. A. and Tsumoto, K
Organizer
DiPiA2010
Place of Presentation
Skipper Hotel. Barcelona,スペイン
Year and Date
20101017-20
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[Presentation] Three Hot-Spot Regions Define the High Affinity of Human Interleukin 15 for its Private alpha-Receptor2009
Author(s)
Caaveiro, J. M. M., Sakamoto, S., Sano, E., Kudou, M. and Tsumoto, K
Organizer
The 23rd Symposium of the Protein Society
Place of Presentation
Boston, Massachusetts, USA
Year and Date
20090724-29
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