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2011 Fiscal Year Final Research Report

Practical control of pathogens which cases stock animal diseases

Research Project

  • PDF
Project/Area Number 21360399
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionTokyo Institute of Technology

Principal Investigator

TANJI Yasunori  東京工業大学, 大学院・生命理工学研究科, 教授 (00282848)

Co-Investigator(Kenkyū-buntansha) MIYANAGA Kazuhiko  東京工業大学, 大学院・生命理工学研究科, 助教 (40323810)
Project Period (FY) 2009 – 2011
Keywordsバクテリオファージ / 乳房炎 / 黄色ブドウ球菌 / Staphylococcus aureus / ファージセラピー / 耐性菌
Research Abstract

49 S. aureus isolates were obtained from the milk of mastitic cows for use in the screening of staphylococcal phages. The host ranges of phages isolated were determined, and two phages were subsequently chosen for analysis.ΦSA039 had the widest host range, producing clear plaques on 13 of the 15 isolates, while□ΦSA012 produced clear plaques on 8 isolates. This study constitutes a solid basis on which to continue the exploration of the potential ofΦSA012 andΦSA039 in the treatment of staphylococcal diseases.

  • Research Products

    (26 results)

All 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (14 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Diffusion of bacteriophages through an artificial biofilm model. Biotechnol. Prog2012

    • Author(s)
      J. Hu, K. Miyanaga, Y. Tanji
    • Journal Title

      DOI

      Volume: 10 Pages: 742

    • Peer Reviewed
  • [Journal Article] Diffusion properties of bacteriophages through agarose gel membrane. Biotechnol2010

    • Author(s)
      J. Hu, K. Miyanaga, Y. Tanji
    • Journal Title

      Prog

      Volume: 26(5) Pages: 1213-1221

    • Peer Reviewed
  • [Journal Article] Intercrossing of Phage Genomes in a Phage Cocktail and Stable Coexistence with Escherichia coli O157 : H7 in Anaerobic Continuous Culture Appl. Microbiol2010

    • Author(s)
      H. Kunisaki, Y. Tanji
    • Journal Title

      Biotechnol

      Volume: 85 Pages: 1533-1541

    • Peer Reviewed
  • [Journal Article] Effect of milk on antibacterial activity of tetracycline against Escherichia coli and Staphylococcus aureus isolated from bovine mastitis. Appl. Microbiol2009

    • Author(s)
      Y. Kuang, H. Jia, K. Miyanaga, Y. Tanji
    • Journal Title

      Biotechnol

      Volume: 84 Pages: 135-142

    • Peer Reviewed
  • [Journal Article] Isolation from sewage influent and characterization of novel Staphylococcus aureus bacteriophages with wide host range and potent lytic capability. Apple. Env2009

    • Author(s)
      A. J. Synnott, Y. Kuang, M. Kurimoto, K. Yamamichi, H. Iwano.Y Tanji
    • Journal Title

      Microbiol

      Volume: 75 Pages: 4283-4490

    • Peer Reviewed
  • [Journal Article] Recombination of T2 bacteriophage using IP008 phage long tail fiber genes expands host range while retaining lytic activity. FEMS Microbiol. Letter, 295, 211-217(2009)(査読有) 7. Y. Kuang, K. Tani, A. J. Synnott, K. Ohshima, H. Higuchi, H. Nagahata, Y. Tanji2009

    • Author(s)
      F. Mahichi. A. J. Synnott, K. Yamamichi, T. Osada, Y. Tanji
    • Journal Title

      Biochem. Eng. J

      Volume: 295 Pages: 211-217

    • Peer Reviewed
  • [Journal Article] Characterization of bacterial population of raw milk from bovine mastitis by culture-independent PCR-DGGE method2009

    • Author(s)
      Y. Kuang, K. Tani, A. J. Synnott, K. Ohshima, H. Higuchi, H. Nagahata, Y. Tanji
    • Journal Title

      Biochem. Eng. J

      Volume: 45 Pages: 76-81

    • Peer Reviewed
  • [Journal Article] IgA response of BALB/c mice to orally administered Salmonella Typhimurium flagellin-displaying T2 bacteriophages2009

    • Author(s)
      A. Synnott, K. Ohshima, Y. Nakai, Y. Tanji
    • Journal Title

      Biotechnol. Prog

      Volume: 25 Pages: 552-558

    • Peer Reviewed
  • [Presentation] 牛乳房炎起因S2011

    • Author(s)
      田中愛里、長田啓太、宮永一彦、永幡肇、岩野英知、樋口豪紀、丹治保典
    • Organizer
      第43回化学工学秋季大会
    • Place of Presentation
      名古屋工業大学
    • Year and Date
      20110914-16
  • [Presentation] バクテリオファージによる病原菌の制御と検出」第16回2011

    • Author(s)
      丹治保典
    • Organizer
      日本乳房炎研究会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2011-10-14
  • [Presentation] Diffusion properties of bacteriophages through a biofilm model, 19 th Biennial Evergreen International Phage Biology Meeting2011

    • Author(s)
      Hu Jun, Y. Tanji
    • Organizer
      The Evergreen State College
    • Place of Presentation
      lympia, WA, USA
    • Year and Date
      2011-09-13
  • [Presentation] Diffusion properties of bacteriophages through agarosegel membrane2010

    • Author(s)
      Hu Jun、丹治保典
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所
    • Year and Date
      20100909-10
  • [Presentation] T4系バクテリオファージの大腸菌O157認識に関わる解析2010

    • Author(s)
      淺川宏章、丹治保典
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所
    • Year and Date
      20100909-10
  • [Presentation] 大腸菌O157感染性ファージの宿主特異性に関する解析2010

    • Author(s)
      森川真年、丹治保典
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所
    • Year and Date
      20100909-10
  • [Presentation] 牛乳房炎由来Staphylococcus aureusとその特異的ファージの相互作用におけるイオン強度の影響2010

    • Author(s)
      栗本実希、丹治保典
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所
    • Year and Date
      20100909-10
  • [Presentation] 牛乳房炎ファージセラピーに向けた取り組み2010

    • Author(s)
      丹治保典
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学蛋白質研究所
    • Year and Date
      20100909-10
  • [Presentation] 牛乳房炎ファージセラピーに向けたS. aureusの凝集性評価2010

    • Author(s)
      丹治保典、谷夏織、栗本実希、宮永一彦、樋口豪紀、岩野英知、井上博紀、永幡肇
    • Organizer
      第15回日本乳房炎研究会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2010-10-22
  • [Presentation] バクテリオファージによる細菌の検出とコントロール2010

    • Author(s)
      丹治保典
    • Organizer
      Bio Japan
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-09-29
  • [Presentation] Two-chamber method to measure diffusion coefficient of bacteriophage in biofilm2009

    • Author(s)
      Hu Jun、宮永一彦、丹治保典
    • Organizer
      第41回化学工学秋季大会
    • Place of Presentation
      広島大学
    • Year and Date
      20090916-18
  • [Presentation] 牛乳房炎のファージセラピー実現に向けた試み2009

    • Author(s)
      丹治保典、宮永一彦、岩野英知
    • Organizer
      第14回日本乳房炎研究会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2009-10-23
  • [Presentation] ファージセラピーは抗生物質治療に取って代われるか2009

    • Author(s)
      丹治保典
    • Organizer
      Bio Japan
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-09
  • [Presentation] wano, Control of Staphylococcus aureus which causes bovine mastitis by bacteriophages with wide host range and potent lytic capability, 18th Biennial Evergreen International Phage Biology Meeting2009

    • Author(s)
      Tanji, A. Synnott, Y. Kuang, M. Kurimoto, K. Yamamichi & H. Iwano
    • Organizer
      The Evergreen State College, Olympia
    • Place of Presentation
      WA, USA, Aug
    • Year and Date
      2009-09-13
  • [Book] ファージと病原菌の奇妙な関係、未来材料2010

    • Author(s)
      丹治保典
  • [Book] バクテリオファージによる大腸菌O157 : H7の同定、臨床検査2009

    • Author(s)
      丹治保典
    • Total Pages
      713-716
  • [Remarks] 本課題研究に関する新聞掲載記事全酪新報、新しい乳房炎の治療法を模索(ファージで原因菌除去) 2011年11月10日

    • URL

      http://www.biochemeng.bio.titech.ac.jp/index.html

  • [Patent(Industrial Property Rights)] スタフィロコッカス・アウレウス溶菌性バクテリオファージ2009

    • Inventor(s)
      丹治保典、宮永一彦、岩野英知、樋口豪紀、井上博紀、永幡肇、横田博、近藤昭宏、小倉俊樹
    • Industrial Property Number
      特許願、2009-183082
    • Filing Date
      2009-12-25

URL: 

Published: 2013-07-31  

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