2011 Fiscal Year Final Research Report
Study on Rapid Optimizing Cell Inductive Differentiation Routes
| Project/Area Number |
21360409
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
FUJIBUCHI Wataru 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究チーム長 (60273512)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Masato 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 連携研究隊長 (60344173)
GOSHIMA Naoki 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 主任研究員 (70215482)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発生分化 / データベース / バイオテクノロジー / 生体生命情報学 |
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| Research Abstract |
Using a gene expression database of mesenchymal stem cells and various cells differentiated from them, we have invented two informatics methods to select candidates of cell differentiation induction factors. In one method we have shown that there are two out of top five candidates actually promote the adipocyte differentiation. In another method we have shown that we use only a few hundreds known data out of about 20, 000 human genes and predict cell differentiation factors with high accuracy. Furthermore, we have established an experimental method to use proteins as combinatorial induction system of multiple factors.
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[Journal Article] CELLPEDIA : a repository for human cell information for cell studies and differentiation analyses2011
Author(s)
Hatano, A., Chiba, H., Moesa, H. A., Taniguchi, T., Nagaie, S., Yamanegi, K., Takai, T., Tanaka, H., Fujibuchi, W.
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DOI
Peer Reviewed
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