脳ペプチドによる摂食行動の脳制御機構とその進化プロセスの解明

2009 Fiscal Year Annual Research Report

• Project/Area Number: 21370025
• Research Institution: University of Toyama
• Principal Investigator: 松田 恒平 University of Toyama, 大学院・理工学研究部(理学), 教授 (60222303)
• Co-Investigator(Kenkyū-buntansha): 高橋 明義 北里大学, 海洋生命科学部, 教授 (10183849) ; 安東 宏徳 九州大学, 大学院・農学研究院, 准教授 (60221743) ; 水澤 寛太 北里大学, 海洋生命科学部, 講師 (70458743)
• Keywords: キンギョ / 神経ペプチド / 摂食行動 / 神経回路 / 自発遊泳行動 / 進化 / 遺伝子発現 / 重動解析

Research Abstract

動物にとって摂食行動は、生命の維持と個体の諸活動を支えるエネルギー獲得のため、欠くことのできない最も重要な本能行動である。本研究は、摂食行動の神経ペプチドによる脳制御機構における進化的背景を探ることを目的として、魚類のモデルとして用いたキンギョにおける機構の解明を目指した。本年度では、キンギョの摂食行動を制御する神経ペプチドの機能解析、特に神経ペプチドの相互作用や神経相関の有無についての解析を進めた。その結果、これまで得ていた神経ペプチドY、オレキシン、グレリン、メラニン凝集ホルモンおよびニワトリ型生殖腺刺激ホルモン放出ホルモンIIによる摂食調節作用に加え、ニューロメジンUはコルチコトロピン放出ホルモンによる作用経路を、オクタデカニューロペプチドは黒色素胞刺激ホルモンによる作用経路を、それぞれ介することにより摂食行動を調節することを新たに見出した。また、神経ペプチドYとメラニン凝集ホルモンによる摂食調節作用は互いに拮抗しながら発揮されることが新たに判った。一方、新規に開発した行動追跡方法により神経ペプチドYとオクタデカニューロペプチドはキンギョの自発遊泳行動に深く影響を及ぼすことを示唆するデータを初めて得た。本研究により、神経ペプチドは、キンギョの摂食行動のみならず情動行動の調節にも深く関与する可能性が示唆された。本年度は、摂食行動の脳調節機構の進化過程を探る上で、水生生活を送る両生類幼生の摂食行動に及ぼす神経ペプチドの影響にも注目した。変態の進行とともにオタマジャクシが摂食行動を停止する理由としてコルチコトロピン放出ホルモンによる摂食抑制作用の可能性を示唆するデータを初めて得た。また、コルチコトロピン放出ホルモンは、両生類幼生において、他の動物種と類似した摂食調節作用を有することが判り、今後の研究を進めるにあたり、大きなヒントを得ることになった。

Research Products

• [Journal Article] The anorexigenic action of the octadecaneuropeptide ODN in goldfish is mediated through the MC4R- and subsequently the CRH receptor-signaling pathways. (2010)
  • Author(s): Matsuda, K., Kojima, K., Wada, K., Maruyama, K., Leprince, J., Tonon, M.C., Uchiyama, M., Vaudry, H.
  • Journal Title: Journal of Molecular Neuroscience (in press)
  • Peer Reviewed
• [Journal Article] Changes in the distribution of corticotropin-releasing factor (CRF)-like immunoreactivity in the larval bullfrog brain and the involvement of CRF in the cessation of food intake during metamorphosis. Gen. Comp. Endocrinol. (2010)
  • Author(s): Matsuda, K., Morimoto, N., Hashimoto, K., Okada, R., Mochida, H., Uchiyama, M., Kikuyama, S.
  • Journal Title: General and Comparative Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Relationship between a-melanocyte-stimulating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus. (2010)
  • Author(s): Kojima, K., Amiya, N., Kamijo, M., Kageyama, H., Uchiyama, M., Shioda, S., Matsuda, K.
  • Journal Title: General and Comparative Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Vasotocin/V2-type receptor/aquaporin axis exists in african lungfish kidney but is functional only in terrestrial condition (2010)
  • Author(s): Konno, N., Hyodo, S., Yamaguchi, Y., Matsuda, K., Uchiyama, M.
  • Journal Title: Endocrinology 151 Pages: 1089-1096
  • Peer Reviewed
• [Journal Article] Biochemical and immunohistochemical analyses of a GnRH-like peptide in the neural ganglia of the pacific abalone haliotis discus hannai (Gastropoda). (2010)
  • Author(s): Amano, M., 他
  • Journal Title: Zoological Science (in press)
  • Peer Reviewed
• [Journal Article] 魚類にみる光と食欲の関連～カレイ目マツカワが教えてくれること (2010)
  • Author(s): 高橋明義
  • Journal Title: Jasco Report (in press)
• [Journal Article] Changes in the plasma levels of insulin-like growth factor-I from the onset of spawning migration through upstream migration in chum salmon. (2010)
  • Author(s): Onuma, T.A., et al., (他9名)
  • Journal Title: Genenal and Comparative Endocrinology 165 Pages: 237-243
  • Peer Reviewed
• [Journal Article] Changes in gene expression for GH/PRL/SL family hormones in the pituitaries of homing chum salmon during ocean migration through upstream migration. (2010)
  • Author(s): Onuma, T.A., et al., (他8名)
  • Journal Title: Genenal and Comparative Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Differential expression of three types of gonadotropin-releasing hormone genes during the spawning season in grass puffer, Takifugu niphobles. (2010)
  • Author(s): Shahjahan, Md., et al., (他4名)
  • Journal Title: Genenal and Comparative Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Aggregating behavior of grass Puffer, Takifugu niphobles, observed in a quarium during the spawning period. (2010)
  • Author(s): Motohashi, E., et al., (他3名)
  • Journal Title: Zoological Science (in press)
  • Peer Reviewed
• [Journal Article] Ghrelin-like peptide with fatty acid modification and O-glycosylation in the red stingray, Dasyatis akajei. (2009)
  • Author(s): Kaiya, H., Kodama, S., Ishiguro, K., Matsuda, K., Uchiyama, M., Miyazato, M., Kangawa, K.
  • Journal Title: BMC Biochemistry doi : 10.1186/1471-2091-10-30
  • Peer Reviewed
• [Journal Article] Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells. (2009)
  • Author(s): Tanaka, M., Azuma, M., Nejigaki, Y., Saito, Y., Mizusawa, K., Uchiyama, M., Takahashi, A., Shioda, S., Matsuda, K.
  • Journal Title: Journal of Endocrinology 203 Pages: 389-398
  • Peer Reviewed
• [Journal Article] Neuromedin U-induced anorexigenic action is mediated by the corticotropin-releasing hormone receptor-signaling pathway in goldfish. (2009)
  • Author(s): Maruyama, K., Wada, K., Ishiguro, K., Shimakura, S.I., Wakasugi, T., Uchiyama, M., Shioda, S., Matsuda, K.
  • Journal Title: Peptides 30 Pages: 2483-2486
  • Peer Reviewed
• [Journal Article] Regulation of food intake by melanin-concentrating hormone in fish. (2009)
  • Author(s): Matsuda, K., Kojima, K., Shimakura, S.I., Takahashi, A.
  • Journal Title: Peptides 30 Pages: 2060-2065
  • Peer Reviewed
• [Journal Article] Molecular cloning and expression of 2 melanin-concentrating hormone receptors in goldfish. (2009)
  • Author(s): Mizusawa, K., Saito, Y., Wang, Z., Kobayashi, Y., Matsuda, K., Takahashi, A.
  • Journal Title: Peptides 30 Pages: 1990-1996
  • Peer Reviewed
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide induces somatolactin release from cultured goldfish pituitary cells. (2009)
  • Author(s): Azuma, M., Tanaka, M., Nejigaki, Y., Uchiyama, M., Takahashi, A., Shioda, S., Matsuda, K.
  • Journal Title: Peptides 30 Pages: 1260-1266
  • Peer Reviewed
• [Journal Article] Recent advances in the regulation of feeding behavior by neuropeptides in fish. (2009)
  • Author(s): Matsuda, K.
  • Journal Title: Annals of the New York of Academy of the Sciences 1163 Pages: 243-252
  • Peer Reviewed
• [Journal Article] Relationship between melanin-concentrating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus. (2009)
  • Author(s): Matsuda, K., Kojima, K., Shimakura, S.I., Miura, T., Uchiyama, M., Shioda, S., Ando, H., Takahashi, A.
  • Journal Title: Comp.Biochem.Physiol.Mol.Integr.Physiol.Part A 153 Pages: 3-7
  • Peer Reviewed
• [Journal Article] Neuronal relationship between orexin-A- and neuropeptide Y-induced orexigenic actions in goldfish. (2009)
  • Author(s): Kojima, K., Kamijo, M., Kageyama, H., Uchiyama, M., Shioda, S., Matsuda, K.
  • Journal Title: Neuropeptides 43 Pages: 63-71
  • Peer Reviewed
• [Journal Article] African lungfish, Protopterus annectens, possess an arginine vasotosin receptor homologous to the tetrapod V2-type receptor. (2009)
  • Author(s): Konno, N., Hyodo, S., Yamaguchi, Y., Kaiya, H., Miyazato, M., Matsuda, K., Uchiyama, M.
  • Journal Title: J.EXP.Biol. 212 Pages: 2183-2193
  • Peer Reviewed
• [Journal Article] Localization and regulation of a facilitative urea transporter in the kidney of the red-eared sli Matsudder turtles (Trachemys scripta). (2009)
  • Author(s): Uchiyama, M., Kikuchi, R., Konno, N., Wakasugi, T., Matsuda, K.
  • Journal Title: J.EXP.Biol. 212 Pages: 249-256
  • Peer Reviewed
• [Journal Article] Purification and properties of ghrelin from the intestine of goldfish, Carassius auratus. (2009)
  • Author(s): Miura, T., Maruyama, K., Kaiya, H., Miyazato, M., Kangawa, K., Uchiyama, M., Matsuda, K.
  • Journal Title: Peptides 30 Pages: 758-765
  • Peer Reviewed
• [Journal Article] White background stimulates the food intake of a pleuronectiform fish the barfin flounder, Verasper moseri (Jordan et Gilbert) (2009)
  • Author(s): Sunuma, T., 他
  • Journal Title: Aquaculture Research 40 Pages: 748-751
  • Peer Reviewed
• [Journal Article] Possible paracrine function of amelanocyte-stimulating hormone and inhibition of its melanin-dispersing activity by N-terminal acetylation in the skin of the barfin flounder, Verasper moseri (2009)
  • Author(s): Kobayashi, Y., 他
  • Journal Title: General and Comparative Endocrinology 161 Pages: 419-424
  • Peer Reviewed
• [Journal Article] Melanin-concentrating hormone : A neuropeptide hormone affecting the relationship between photic environment and fish with special reference to background color and food intake regulation (2009)
  • Author(s): Amano, M., 他
  • Journal Title: Peptides 30 Pages: 1979-1984
  • Peer Reviewed
• [Journal Article] Immunological Characterization and Distribution of Three GnRH Forms in the Brain and Pituitary Gland of Chub Mackerel (Scomber japonicus) (2009)
  • Author(s): Selvaraj, S., 他
  • Journal Title: Zoological Science 26 Pages: 828-839
  • Peer Reviewed
• [Journal Article] Biochemical analysis and immunohistochemical examination of a GnRH-like immunoreactive peptide in the central nervous system of a decapod crustacean the kuruma prawn (Marsupenaeus japonicus) (2009)
  • Author(s): Amano, M., 他
  • Journal Title: Zoological Science 26 Pages: 840-845
  • Peer Reviewed
• [Journal Article] 光環境と魚類生理-マツカワの無眼側黒化から成長促進へ (2009)
  • Author(s): 山野目健, 他
  • Journal Title: 比較内分泌学 35 Pages: 93-98
• [Journal Article] Elevation of the plasma level of insulin-like growth factor-I with reproductive maturation prior to initiation of spawning migration of chumsalmon. (2009)
  • Author(s): Onuma, T.A., et al., (他7名)
  • Journal Title: Annals of the New York Academy of Sciences 1163 Pages: 497-500
  • Peer Reviewed
• [Journal Article] Synchronized diurnal and circadian expressions of four subtypes of melatonin receptor genes in the diencephlon of a puffer fish with lunar-related spawning cycles. (2009)
  • Author(s): Ikegami, T., et al., (他4名)
  • Journal Title: Neuroscience Letters 462 Pages: 58-63
  • Peer Reviewed
• [Journal Article] Osmoregulatory responses of expression of vasotocin, isotocin, prolactin and growth hormone genes following hypoosmotic challenge in a stenohaline marine teleost, tiger puffer (Takifugu rubripes). (2009)
  • Author(s): Motohashi, E., et al., (他3名)
  • Journal Title: Comparative Biochemistry and Physiology Part A 154 Pages: 353-359
  • Peer Reviewed
• [Presentation] 神経ペプチドによるキンギョの摂食調節と情動制御機構の解析 (2010)
  • Author(s): 松田恒平, 他
  • Organizer: 第9回水生動物の行動と神経系シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 20100123-20100124
• [Presentation] Effect of neuropeptide Y on emotional behavior in goldfish (2010)
  • Author(s): Matsuda, K., 他
  • Organizer: Satellite Symposium of the 14th International Congress of Endocrinology "Neuroendocrine Functions of GPCRs"
  • Place of Presentation: 京都
  • Year and Date: 2010-03-31
• [Presentation] The mechanism underlying the anorexigenic action of curry spice curcumin (2010)
  • Author(s): Kang, K., 他
  • Organizer: Satellite Symposium of the 14th International Congress of Endocrinology "Neuroendocrine Functions of GPCRs"
  • Place of Presentation: 京都
  • Year and Date: 2010-03-31
• [Presentation] Somatolactin release from cultured goldfish pituitary cells in regulated by PACAP and MCH (2010)
  • Author(s): Azuma, M., 他
  • Organizer: Satellite Symposium of the 14th International Congress of Endocrinology "Neuroendocrine Functions of GPCRs"
  • Place of Presentation: 京都
  • Year and Date: 2010-03-31
• [Presentation] Changes in the distribution of corticotropin-releasing factor (CRF)-like immunoreactivity in the bullfrog tadpole brain and involvement of CRF in the cessation of feeding behavior during metamorphosis (2010)
  • Author(s): Morimoto, N., 他
  • Organizer: Satellite Symposium of the 14th International Congress of Endocrinology "Neuroendocrine Functions of GPCRs"
  • Place of Presentation: 京都
  • Year and Date: 2010-03-31
• [Presentation] Effect of feeding condition on the neuropeptide Y (NPY)- and orexin (ORX)-like immunoreactivities, and their mRNA expression levels in the zebrafish brain and development of a method for measuring feeding behavior in zebrafish (2010)
  • Author(s): Yokobori, E., 他
  • Organizer: Satellite Symposium of the 14th International Congress of Endocrinology "Neuroendocrine Functions of GPCRs"
  • Place of Presentation: 京都
  • Year and Date: 2010-03-31
• [Presentation] クロマグロのグレリン遺伝子のクローニングと発現解析 (2010)
  • Author(s): 須田敦, (他5名)
  • Organizer: 平成22年度日本水産学会春季大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-29
• [Presentation] Angiotensin II through type 1(AT1)-like receptor stimulaates water intake from the skin in the Japanese treefrog (2010)
  • Author(s): Minoru Uchiyama, Sho Maejima, Nonifumi Konno, Kouhei Matsuda
  • Organizer: 6th Intercongress Symposium of the Asia Oceania society for Comparative Endocrinology
  • Place of Presentation: PalmerrstonNorth, New Zealand
  • Year and Date: 2010-01-22
• [Presentation] Molecular cloning and distribution of opioid receptors in goldfish : exploring novel functions of opioid peptides in fish (2010)
  • Author(s): Takahashi, A.
  • Organizer: Sixth intercongress symposium of the Asia and Oceania society for comparative endocrinology
  • Place of Presentation: Palmerston North, New Zealand
  • Year and Date: 2010-01-20
• [Presentation] 両生類の腹皮による水飲みにおけるバソトシンの作用 (2010)
  • Author(s): 前嶋翔、今野紀文、松田恒平、内山実
  • Organizer: 第20回バソプレシン研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-09
• [Presentation] キンギョの摂食行動と情動行動に及ぼすオクタデカニューロペプチド(ODN)の影響 (2009)
  • Author(s): 松田恒平、和田亘平、Jerome Leprince、Marie-Christine Tonon、丸山圭介、内山実、Hubert Vaudry
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] キンギョ脳内における摂食調節ペプチド含有ニューロンの神経相関 (2009)
  • Author(s): 小島健史、島倉征一、中町智哉、影山晴秋、内山実、高橋明義、塩田清二、松田恒平
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] 肺魚からみたアクアポリン(AQP)遺伝子の分子進化 (2009)
  • Author(s): 今野紀文、兵藤晋、北村咲奈、松田恒平、内山実
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] ニホンアマガエルHyla japonicaの吸水とその調節 (2009)
  • Author(s): 露谷孔明、前嶋翔、今野紀文、松田恒平、内山実
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] イソギンポ科3魚種における鰓の構造並びにイオン輸送体の分布 (2009)
  • Author(s): 小宮山牧子、吉澤英樹、清水則雄、今野紀文、松田恒平、内山実
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] 生息環境の異なるイソギンポ科3魚種における腎ネフロン構造と細胞輸送体の分布 (2009)
  • Author(s): 田中美沙樹、吉澤英樹、清水則雄、今野紀文、松田恒平、内山実
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] アマガエルにおけるAng II及びAVT前駆体cDNAの単離と体液変動時の発現 (2009)
  • Author(s): 前嶋翔、今野紀文、松田恒平、内山実
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] 水槽内における産卵期のクサフグの集合行動 (2009)
  • Author(s): 本橋英治, (他2名)
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] Quantitative expression analysis of LPXRFa and its receptor genes during the spawning season in grass puffer. (2009)
  • Author(s): Shahjahan, Md., (他2名)
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: 静岡
  • Year and Date: 20090917-20090920
• [Presentation] Effect of the diazepam-binding inhibitor-derived peptide, octadecaneuropeptide, on feeding and emotional behaviors in goldfish 招待講演 (2009)
  • Author(s): Kouhei Matsuda, Kohei Wada, Jerome Leprince, Marie-Christine Tonon, Keisuke Maruyama, Minoru Uchiyama, Hubert Vaudry
  • Organizer: 16^<th> International Congress of Comparative Endocrinology (ICCE2009)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090622-20090626
• [Presentation] PACAP and MCH regulates somatolactin release from cultured goldfish pituitary cells (2009)
  • Author(s): Morio Azuma, Mio Tanaka, Yumiko saito, Minoru Uchiyama, Kanta Mizusawa, Akiyoshi Takahashi, Seiji Shioda, Kouhei Matsuda
  • Organizer: 16^<th> International Congress of Comparative Endocrinology (ICCE2009)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090622-20090626
• [Presentation] Role of neuromedin U and its receptor on the feeding regulation in goldfish (2009)
  • Author(s): Keisuke Maruyama, Kohei Wada, Norifumi Konno, Hiroyuki Kaiya, Minoru Uchiyama, Seiji Shioda, Kouhei Matsuda
  • Organizer: 16^<th> International Congress of Comparative Endocrinology (ICCE2009)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090622-20090626
• [Presentation] Orexin system in the brain flounder (2009)
  • Author(s): Noriko Amiya, Yuki Kobayashi, Kanta Mizusawa, Takeshi Yamanome, Masayuki Iigo, Toshikazu Sunuma, Kouhei Matsuda, Akiyoshi Takahashi, Masafumi Amano
  • Organizer: 16^<th> International Congress of Comparative Endocrinology (ICCE2009)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090622-20090626
• [Presentation] Effect of the diazepam-binding inhibitor-derived peptide, octadecaneuropeptide, on feeding and emotional behaviors in goldfish (2009)
  • Author(s): Kouhei Matsuda, Kohei Wada, Jerome Leprince, Marie-Christine Tonon, Keisuke Maruyama, Minoru Uchiyama, Hubert Vaudry
  • Organizer: 16^<th> International Congress of Comparative Endocrinology (ICCE2009)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090622-20090626
• [Presentation] Cloning of angitensin II receptors and their expressions during osmotic stress in the bullfrog, Rana catesbeiana (2009)
  • Author(s): Minoru Uchiyama, Syohei Kitani, Sho Maejima, Norihumi Konno, Kouhei Matsuda
  • Organizer: 16^<th> International Congress of Comparative Endocrinology (ICCE2009)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090622-20090626
• [Presentation] Central effects of angiotensin II and arginine vasotocin on warter absorption behavior in Japanese tree frog, Hyla japonica (2009)
  • Author(s): Sho Maejima, Norihumi Konno, Kouhei Matsuda, Minoru Uchiyama
  • Organizer: 16^<th> International Congress of Comparative Endocrinology (ICCE2009)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 20090622-20090626
• [Presentation] クサフグの間脳における4種類のメラトニン受容体遺伝子の同期的概日発現 (2009)
  • Author(s): 池上太郎, (他1名)
  • Organizer: 第62回日本動物学会九州支部大会
  • Place of Presentation: 宮崎
  • Year and Date: 20090523-20090524
• [Presentation] Correlated expression of Kiss2 and Kiss2r genes during the spawning season in grass puffer. (2009)
  • Author(s): Shahjahan, Md., (他1名)
  • Organizer: 第62回日本動物学会九州支部大会
  • Place of Presentation: 宮崎
  • Year and Date: 20090523-20090524
• [Presentation] 黒色素胞刺激ホルモンはマツカワ頭腎からのコルチゾル分泌を刺激する (2009)
  • Author(s): 小林勇喜
  • Organizer: 第34回日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-23
• [Presentation] ゼブラフィッシュにおけるNPYとORXの脳内分布と摂食行動解析法の確立 (2009)
  • Author(s): 横堀絵理、小島健史、阿見弥典子、今野紀文、内山実、松田恒平
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] トラフグの摂食行動に及ぼすNPYの影響 (2009)
  • Author(s): 上條元規、小島健史、本橋英治、池上太郎、丸山圭介、安東宏徳、内山実、松田恒平
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] ウシガエルの摂食行動に及ぼすコルチコトロピン放出因子(CRF)の影響 (2009)
  • Author(s): 森本憲明、橋本宗祐、菊山榮、松田恒平
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] キンギョの情動行動に及ぼすオクタデカニューロペプチドの影響 (2009)
  • Author(s): 松田恒平、和田亘平、Jerome Leprince、Marie-Christine Tonon、坂下敦、矢橋里和、内山実、Hubert Vaudry
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] カレイ目マツカワにおけるNPYとグレリンcDNAの同定 (2009)
  • Author(s): 阿見弥典子、小林勇喜、水澤寛太、山野目健、高橋明義、天野勝文、松田恒平
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] 無尾両生類の水分摂取行動におけるアンジオテンシンIIによる調節 (2009)
  • Author(s): 前嶋翔、今野紀文、松田恒平、内山実
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] クサフグ松果体におけるPer, AANAT, MelRサブタイプ遺伝子の日周発現 (2009)
  • Author(s): 池上太郎, (他4名)
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] Synchronized diurnal and circadian expressions of Kiss2 and Kiss2r genes in grass puffer. (2009)
  • Author(s): Shahjahan, Md., (他3名)
  • Organizer: 第34回 日本比較内分泌学会大会・日本比較生理生化学会第31回大会合同大会(CompBiol2009)
  • Place of Presentation: 大阪
  • Year and Date: 2009-10-22
• [Presentation] PACAP stimulates somatolactin release from cultured goldfish pituitary cells招待講演 (2009)
  • Author(s): Kouhei Matsuda, Morio Azuma , Akiyoshi Takahashi
  • Organizer: The 9^<th> International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: 鹿児島
  • Year and Date: 2009-10-06
• [Presentation] Recent advances in the regulation of food intake by neuropeptides in goldfish招待講演 (2009)
  • Author(s): Kouhei Matsuda
  • Organizer: Satellite Symposium of the 9^<th> International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: 屋久島、鹿児島
  • Year and Date: 2009-10-03
• [Presentation] 水槽色はサクラマスの海水適応に影響するか? (2009)
  • Author(s): 山野目健
  • Organizer: 平成21年度日本水産学会秋季大会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-10-02
• [Presentation] マツカワの頭腎におけるメラノコルチンのコルチゾル分泌能 (2009)
  • Author(s): 小林勇喜
  • Organizer: 平成21年度日本水産学会秋季大会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-10-01
• [Presentation] Distribution of corticotropin-releasing factor (CRF)-immunoreactivity in the bullfrog brain : central effect of CRF on the inhibition of food intake in the bullfrog (2009)
  • Author(s): Matsuda, K., 他
  • Organizer: 6^<th> International Symposium on Amphibian and Reptilian Endocrinology and Neurobiology
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2009-09-22
• [Presentation] 摂食制御ペプチドの機能解析-本能行動の脳制御機構の進化プロセスの解明を目指して- 招待講演 (2009)
  • Author(s): 松田恒平
  • Organizer: 第11回応用薬理シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-18
• [Presentation] 神経ペプチドによる下等脊椎動物の摂食行動の制御機構:ウシガエルの摂食行動に及ぼす副腎皮質刺激ホルモン放出因子の影響 招待講演 (2009)
  • Author(s): 松田恒平、森本憲明、橋本宗祐、菊山榮
  • Organizer: 日本動物学会第80回大会シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-17
• [Presentation] Neuroendocrine regulation of spawning behavior in grass puffer, Takifugu niphobles. (2009)
  • Author(s): Hironori Ando
  • Organizer: 中国動物学会比較内分泌学分会第八回学術会議
  • Place of Presentation: 麗江、中国
  • Year and Date: 2009-09-15
• [Presentation] マツカワの皮膚および脳下垂体におけるPOMCシステム (2009)
  • Author(s): 小林勇喜
  • Organizer: 第24回日本下垂体研究会
  • Place of Presentation: 三沢、青森
  • Year and Date: 2009-08-28
• [Presentation] 産卵期のクサフグの集合行動は水槽内でも起こる (2009)
  • Author(s): 本橋英治, (他1名)
  • Organizer: 第8回九州地区動物生理学談話会
  • Place of Presentation: 九重、大分
  • Year and Date: 2009-08-20
• [Presentation] クサフグの月周同期産卵リズムの解析:メラトニン情報伝達系からのアプローチ (2009)
  • Author(s): 池上太郎, (他1名)
  • Organizer: 第8回九州地区動物生理学談話会
  • Place of Presentation: 九重、大分
  • Year and Date: 2009-08-20
• [Presentation] Neuroendocrine regulation of reproduction in grass puffer, Takifugu niphobles. (2009)
  • Author(s): Shahjahan, Md., (他1名)
  • Organizer: 第8回九州地区動物生理学談話会
  • Place of Presentation: 九重、大分
  • Year and Date: 2009-08-20
• [Presentation] Molecular cloning of 3 opioid receptors in goldfish (2009)
  • Author(s): Imanaka, Y.
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2009-06-25
• [Presentation] Identification of cells expressing proopiomelanocortin and its receptors in the skin of barfin flounder (2009)
  • Author(s): Kobayashi, Y.
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2009-06-23
• [Presentation] Characterization of two melanin-concentrating hormone receptor subtypes in goldfish (2009)
  • Author(s): Mizusawa, K.
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2009-06-23
• [Presentation] Regulation of food intake in goldfish : novel aspects of melanin-concentrating hormone 招待講演 (2009)
  • Author(s): Kouhei Matsuda
  • Organizer: The 2nd International Symposium for Fish Growth & Reproduction (ISFGR)
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2009-06-20
• [Presentation] 下等脊椎動物における摂食調節機構-神経ペプチド作用の進化を探る- 招待講演 (2009)
  • Author(s): 松田恒平
  • Organizer: 第6回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-09
• [Presentation] キンギョの摂食行動と情動行動に及ぼすジアゼパム結合阻害物質由来ペプチドoctadecaneuropeptideの影響 (2009)
  • Author(s): 和田亘平、Jerome Leprince、Marie-Christine Tonon、丸山圭介、内山実、Hubert Vaudry、松田恒平
  • Organizer: 第6回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-09
• [Presentation] PACAPとMCHはキンギョ下垂体初代培養細胞のソマトラクチン分泌を制御する (2009)
  • Author(s): 東森生、田中爾織、水澤寛太、内山実、高橋明義、斎藤裕見子、塩田清二、松田恒平
  • Organizer: 第6回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-09
• [Remarks]
  • URL: http://www.sci.u-toyama.ac.jp/bio/kmatsuda.html